Value of Imaging Findings in the Prediction of Microvascular Invasion in Hepatocellular Carcinoma |
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| Institution: | 1. Department of Radiology, Istanbul Bilim University, Sisli Florence Nightingale Hospital, Istanbul, Turkey;2. Department of Medical Oncology, Istanbul Bilim University, Sisli Florence Nightingale Hospital, Istanbul, Turkey;3. Department of Liver Transplantation, Istanbul Bilim University, Sisli Florence Nightingale Hospital, Istanbul, Turkey;1. Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan;2. Department of Radiology, Far Eastern Memorial Hospital, New Taipei City, Taiwan;3. Division of Gastroenterology, Far Eastern Memorial Hospital, New Taipei City, Taiwan;1. Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin;2. The Transplant Center, Froedtert and The Medical College of Wisconsin, Milwaukee, Wisconsin;3. Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin;4. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin;1. Department of Radiology, Istanbul Bilim University, Sisli Florence Nightingale Hospital, Istanbul, Turkey;2. Department of Nuclear Medicine, Istanbul Bilim University, Sisli Florence Nightingale Hospital, Istanbul, Turkey;3. Department of Liver Transplantation, Istanbul Bilim University, Sisli Florence Nightingale Hospital, Istanbul, Turkey;1. AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire, Villejuif, France;2. Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Tokyo, Japan;3. Unités Mixtes de Recherche en Santé, Villejuif, France;4. Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France;5. Unités Mixtes de Recherche en Santé, INSERM, Villejuif, France;1. Departments of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania;2. Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania;3. Division of Interventional Radiology, Department of Radiology, Yale School of Medicine, 330 Cedar Street, TE 2-224, New Haven, CT 06510;4. Yale Cancer Center, New Haven, Connecticut.;1. Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan;2. Department of Radiology, Far Eastern Memorial Hospital, New Taipei City, Taiwan;3. Division of Gastroenterology, Far Eastern Memorial Hospital, New Taipei City, Taiwan;4. Division of Hematology and Oncology, Far Eastern Memorial Hospital, New Taipei City, Taiwan |
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| Abstract: | BackgroundThe purpose of this study was to determine the utility of some imaging findings in predicting microvascular invasion (MVI) and hepatocellular carcinoma (HCC) recurrence risk after liver transplantation.MethodThis retrospective study included 123 patients with histopathologically proven HCC at explant. All HCCs were classified as MVI positive (group I) or negative (group II) based on histopathological findings. In each group, multifocality, largest tumor size, bulging (tumor causing liver capsule expansion), beak sign (the acute angle between the tumor and liver parenchyma), and diffusion restriction on diffusion weighted images (DWI) were evaluated. These findings were compared between the groups by Student’s t test. The relation between the parameters and MVI was analyzed by using the Spearman’s correlation test.ResultsOf the total patients, 30.1% had MVI (group I) and 69.9% (group II) did not have MVI. Presence of beak sign (P ≤ .005), bulging sign (P = .002), and diffusion restriction (P = .045) were significantly more frequent in group I than group II. The beak sign, bulging sign, and diffusion restriction were correlated with presence of MVI. Largest tumor size and multifocality were higher in group I than group II, but the differences were not statistically significant.ConclusionRadiologists and transplant surgeons should be aware of some clue imaging findings, especially beak and bulging signs because these findings may predict the presence of MVI in HCC. These patients might benefit from histologic confirmation of the tumor characteristics through biopsy and subsequent bridging treatment options before liver transplantation to reduce the risk of recurrence. |
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