乙肝肝硬化与慢性乙肝患者生化指标的比较

目的 比较肝硬化和慢性乙肝患者生化指标的差异,为乙型肝炎肝硬化病情早期发现和有效治疗提供实验室依据.方法 收集绵阳市中心医院2019年3月-2020年11月诊治的259例乙型肝炎肝硬化患者(乙肝肝硬化组)、同期本院诊治的慢性乙肝患者203例(乙肝组)临床资料和体检正常的健康志愿者233例(对照组),分别检测血清D-二聚...

Comparison of biochemical indicators between patients with liver cirrhosis and those with chronic hepatitis B

Objective To compared the levels of biochemical indicators between patients with liver cirrhosis and those with chronic hepatitis B, so as to provide a laboratory basis for early detection and effective treatment of hepatitis B cirrhosis. Methods The clinical data of 259 patients with hepatitis B cirrhosis diagnosed and treated in Mianyang Central Hospital between March 2019 and November 2020 were retrospectively analyzed. Meanwhile, 203 patients with chronic hepatitis B (hepatitis B group) and 233 healthy volunteers (control group) were selected. The levels of serum D-dimer (D-D), albumin (ALB), total bilirubin (TBil), matrix metalloproteinase (MMP-2), and macrophage colony stimulating factor (M-CSF) were detected, and compared among the 3 groups. Child-pugh classification of patients with hepatitis B cirrhosis included grade A, grade B and grade C. The correlation of serum D-D, ALB, TBil, MMP-2 and M-CSF levels with the severity of the disease was analyzed. Results Serum D-D, ALB, TBil, MMP-2 and M-CSF levels in the hepatitis B cirrhosis group were (2.51±1.10) mg/L, (20.92±3.45) g/L, (62.42±20.41) µmol/L, (262.31±32.62) ng/mL and (348.89±26.03) pg/mL. The levels in the hepatitis B group were (1.23±0.51) mg/L, (34.81±4.23) g/L, (36.25±17.48) µmol/L, (216.43±25.86) ng/mL and (312.72±58.83) pg/mL, which in the control group were (0.29±0.11) mg/L, (45.16±1.92) g/L, (15.76±3.62) µmol/L, (153.26±17.35) ng/mL and (246.58±30.24) pg/mL. The items among the three groups were highest in hepatitis B cirrhosis group, the differences were statistically significant (P<0.01). The positive rates of serum D-D, ALB, TBil, MMP-2 and M-CSF were significantly different in patients with different grades of liver function, showing grade A Conclusion sThere are abnormal changes of serum D-D, ALB, TBil, MMP-2 and M-CSF levels in patients with hepatitis B cirrhosis. All of the indicators are related to the degree of liver damage. The combination of serum MMP-2, D-D and ALB is with high sensitivity, which can help evaluate the patients’ condition and guide treatment.