弓形虫感染与神经精神疾病的关系研究进展

刚地弓形虫是一种世界范围内广泛分布的机会性致病原虫,能引起人兽共患的弓形虫病,严重威胁着人类的健康。近年来,刚地弓形虫感染与精神疾病的关系越来越受到重视。弓形虫感染对神经系统的影响与多种神经精神疾病的发病有关,如精神分裂症、抑郁症,阿尔兹海默症等。本文综述弓形虫感染与神经精神疾病之间的关系及可能存在的致病机制,通过相关致病机制的研究,期望能为临床治疗弓形虫感染导致的神经精神疾病提出新的治疗方向和可行方案。

Review of relationship between Toxoplasma gondii infection and neuropsychiatric diseases

Toxoplasma gondii, an opportunistic pathogenic protozoan, is widely distributed worldwide and can cause zoonoses, which is a serious threat to human health. Nowadays, the relationship between T. gondii infection and neuropsychiatric diseases has attracted researchers' attention increasingly. T. gondii infection is related to the pathogenesis of many neuropsychiatric diseases by affecting the nervous system, such as schizophrenia, depression, Alzheimer's disease, and so on. This review will focus on the relationship between T. gondii infection and neuropsychiatric diseases and summarizes the possible mechanisms of disorders resulting from T. gondii infection． It is expected that the study on the related pathogenic mechanism of T. gondii will lead to new therapeutic directions and feasible solution for the clinical treatment of neuropsychiatric diseases caused by T. gondii infection.