细胞色素P450介导蚊虫代谢抗性及防治应用的相关研究进展

随着化学杀虫剂在公共卫生和农业上的长期大量应用，导致蚊虫抗药性的发生与发展，从而为病媒疾病的控制带来了前所未有的挑战。目前研究表明代谢抗性是蚊虫抗性中主要的抗性机制之一，其中细胞色素P450作为代谢抗性相关酶类中重要的酶系家族，参与了蚊虫内源及外源化合物的生物转化和代谢。细胞色素P450介导蚊虫代谢抗药性的酶系主要是CYP6、CYP9和CYP4家族。近年来随着生物信息学和分子生物学技术的发展，蚊虫全基因组水平抗性基因及抗性机制取得更全面和深入的研究，越来越多的CYP被发现和证实与蚊虫的抗药性相关，并且应用于相关病媒控制及抗性管理中。本综述介绍了CYPs在蚊虫代谢抗性方面的基础研究情况，以及在蚊虫防治及蚊虫抗性管理中的相关研究进展。

Development of cytochrome P450 in mediating metabolic resistance and applications for mosquito control

With the long-term and large-scale application of chemical insecticides in public health and agricultural sectors, the occurrence and development of mosquito resistance has led to unprecedented challenges for the control of vector diseases. At present, studies have shown that metabolic resistance is one of the main resistance mechanisms of mosquito resistance.Cytochrome P450, as an important family of enzymes related to metabolic resistance, participates in the biotransformation and metabolism of endogenous and exogenous compounds in mosquitoes. CYP6, CYP9 and CYP4 families are the main enzymes of cytochrome P450 mediated mosquito metabolic resistance. In recent years, with the development of bioinformatics and molecular biology technology, more comprehensive and in-depth studies have been made on mosquito genome-wide resistance genes and resistance mechanisms. More and more CYPs have been found and confirmed to be related to mosquito drug resistance and applied to related vector control and resistance management. This paper briefly introduces the basic research of CYPs in mosquito metabolic resistance, as well as the related research progress in mosquito control and mosquito resistance management.