宁夏2020年重点地区一般人群流行性出血热抗体水平监测

目的 2020年在宁夏流行性出血热自然疫源地县区开展一般人群流行性出血热抗体水平调查,了解辖区居住一般人群免疫水平.方法 采用分层整群随机抽样方法,抽取宁夏近年来流行性出血热自然疫源地和近年来有病例报告的6个县(区)18个乡镇36个村,每个村随机抽取25人,每人采集静脉血4mL,采用酶联免疫吸附试验(ELISA)检测血...

Antibody level of epidemic hemorrhagic fever among general population in key monitoring areas of Ningxia in 2020

Objective To investigate the antibodies of epidemic hemorrhagic fever among the general population in the natural foci of Ningxia, and to understand the general population's immune level. Methods There are 18 towns under the jurisdiction of 6 districts which are natural foci of epidemic hemorrhagic fever and have been reported epidemic hemorrhagic fever cases in recent years in Ningxia. We sampled 36 villages in these regions by stratified cluster random sampling method, twenty-five people were randomly selected from each village and collected 4 mL of venous blood for each person, and used enzyme-linked immunosorbent assay (ELISA) to detect epidemic hemorrhagic fever serum IgG antibodies. Results A total of 962 sera from the general population were collected in this survey, of which 78 were IgG antibody positive after detection and the total positive rate was 8.11%. And the IgG antibody positive rate in Longde county was the highest (20.00%), followed by Yuanzhou county was 13.34%, Jingyuan county was 7.95%, Xiji county was 7.50%, Pengyang county was 0.67%, the IgG antibody positive rate in Haiyuan county was the lowest (0). The positive rate of IgG antibody of epidemic hemorrhagic fever in general population of different counties was statistically significant. There was no significant difference in antibody positive rate among different genders, occupations and educational levels. However, the difference in antibody positive rate between different ages was statistically significant. The antibody-positive rate of people who have suffered from epidemic hemorrhagic fever is higher than those who are not sick, and those who have been vaccinated is higher than people who have not been vaccinated. With the passage of time, the positive rate of antibody in vaccinated population decreased. Conclusions People in the natural foci of epidemic hemorrhagic fever in Ningxia have a low level of immune status, and an effective immune barrier has not been formed, which may cause an outbreak. Therefore, it is recommended to further launch patriotic health campaigns and improve the home environment. In addition, it is necessary to prevent rodent damage , carry out health education, carry out vaccination of susceptible populations and comprehensive prevention and control measures and so on. To improve people's ability to prevent diseases and coverage and compliance of vaccination, strengthen and build an immune barrier. To move forward a single step reduce the risk of the outbreak and ensuring the health of people in epidemic areas.