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Innate immune crosstalk in asthmatic airways: Innate lymphoid cells coordinate polarization of lung macrophages
Institution:1. Laboratory of Mucosal Immunology in the Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea;3. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea;4. Department of Pathology, Seoul National University College of Medicine, Seoul, Korea;5. Laboratory of Immune Regulation in the Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea;2. Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea;1. Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan;2. Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;3. Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan;4. Department of Tropical Medicine, Hawaii Center for AIDS, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii;5. Section of Pharmacology, Department of Medicine, University of Perugia, Perugia, Italy;6. Laboratory of Molecular Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan;1. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, Calif;2. Janssen Research and Development, San Diego, Calif;3. Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Mass;4. Department of Microbiology and Immunology, Harvard Medical School, Boston, Mass;1. Institute for Biomaterials, Korea University, Seoul, Korea;2. Interdisciplinary Program in Precision Public Health, Korea University, Seoul, Korea;3. Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, Korea;4. Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea;5. Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea;6. Department of Internal Medicine, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea;7. Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea;8. Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea;9. Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea;10. Allergy and Clinical Immunology Research Center, Hallym University College of Medicine, Chuncheon, Korea;11. Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea;12. School of Biosystems and Biomedical Sciences, Korea University, Seoul, Korea;1. Laboratory of Cellular and Molecular Immunology, GIGA Research, University of Liège, 4000 Liège, Belgium;2. Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium;3. Singapore Immunology Network, Agency for Science, Technology, and Research, Singapore 138648, Singapore;4. Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, London W2 1PG, UK;5. Laboratory of Immunology-Vaccinology, Fundamental and Applied Research for Animals & Health, University of Liège, 4000 Liège, Belgium;6. Centre de Recherche sur les Protéines Prion, Department of Human Histology, University of Liège, 4000 Liège, Belgium;7. INSERM U1019, CNRS UMR 8204, Center for Infection and Immunity of Lille, University of Lille, CHU Lille, Institut Pasteur de Lille, 59000 Lille, France;8. Laboratory of Tumor and Developmental Biology, GIGA Research, University of Liège, 4000 Liège, Belgium;9. Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK;10. Walloon Excellence in Life Sciences and Biotechnology, Wallonia, Belgium;1. Department of Medicine, Division of Allergy & Immunology, National Jewish Health, Denver, Colo;2. School of Medicine, University of Colorado Denver, Denver, Colo;3. Department of Cytobiology and Proteomics, Medical University of Lodz, Lodz, Poland;1. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, Los Angeles, California 90033, USA;2. Janssen Research and Development, San Diego, California 92121, USA;3. Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA;4. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Abstract:
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  • Keywords:Asthma  innate lymphoid cells  macrophage  polarization  induced sputum  asthma phenotype  AHR"}  {"#name":"keyword"  "$":{"id":"kwrd0045"}  "$$":[{"#name":"text"  "_":"Airway hyperresponsiveness  AM"}  {"#name":"keyword"  "$":{"id":"kwrd0055"}  "$$":[{"#name":"text"  "_":"Alveolar macrophage  Arg1"}  {"#name":"keyword"  "$":{"id":"kwrd0065"}  "$$":[{"#name":"text"  "_":"Arginase 1  CD40L"}  {"#name":"keyword"  "$":{"id":"kwrd0075"}  "$$":[{"#name":"text"  "_":"CD40 ligand  CRTH2"}  {"#name":"keyword"  "$":{"id":"kwrd0085"}  "$$":[{"#name":"text"  "$$":[{"#name":"__text__"  "_":"Chemoattractant receptor–homologous molecule expressed on T"}  {"#name":"inf"  "$":{"loc":"post"}  "_":"H"}  {"#name":"__text__"  "_":"2 cells  ICOS"}  {"#name":"keyword"  "$":{"id":"kwrd0095"}  "$$":[{"#name":"text"  "_":"Inducible T-cell costimulator  ILC"}  {"#name":"keyword"  "$":{"id":"kwrd0105"}  "$$":[{"#name":"text"  "_":"Innate lymphoid cell  ILC1"}  {"#name":"keyword"  "$":{"id":"kwrd0115"}  "$$":[{"#name":"text"  "_":"Group 1 innate lymphoid cell  ILC2"}  {"#name":"keyword"  "$":{"id":"kwrd0125"}  "$$":[{"#name":"text"  "_":"Group 2 innate lymphoid cell  ILC3"}  {"#name":"keyword"  "$":{"id":"kwrd0135"}  "$$":[{"#name":"text"  "_":"Group 3 innate lymphoid cell  IL-7R"}  {"#name":"keyword"  "$":{"id":"kwrd0145"}  "$$":[{"#name":"text"  "_":"IL-7 receptor  Nos2"}  {"#name":"keyword"  "$":{"id":"kwrd0155"}  "$$":[{"#name":"text"  "_":"Nitric oxide synthase 2  Mrc1"}  {"#name":"keyword"  "$":{"id":"kwrd0165"}  "$$":[{"#name":"text"  "_":"Mannose receptor C type 1  NCR"}  {"#name":"keyword"  "$":{"id":"kwrd0175"}  "$$":[{"#name":"text"  "_":"Natural cytotoxicity receptor  PD-1"}  {"#name":"keyword"  "$":{"id":"kwrd0185"}  "$$":[{"#name":"text"  "_":"Programmed cell death protein 1  Retnla"}  {"#name":"keyword"  "$":{"id":"kwrd0195"}  "$$":[{"#name":"text"  "_":"Resistin-like molecule α
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