托珠单抗治疗幼年特发性关节炎相关葡萄膜炎的研究进展

葡萄膜炎是幼年特发性关节炎（JIA）最常见的关节外表现，多表现为反复发作的慢性前葡萄膜炎，其发病隐匿、并发症多等特点可导致患者眼部结构损伤、视力丧失。白细胞介素6（IL-6）是一种多效性细胞因子，参与炎症反应和免疫调节等过程，而托珠单抗是一种人源性IL-6受体（IL-6R）单克隆抗体，通过竞争性与IL-6R结合从而抑制...

Progress of Tocilizumab in the Treatment of Juvenile Idiopathic Arthritis Associated Uveitis

Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA). Thecommonest form of uveitis seen in JIA is recurrent chronic antetior uveitis with insidious onset andcomplications, which can lead to ocular structural damage and vision loss. Interleukin-6 (IL-6) is apleiotropic cytokine and it can promote inflammatory response and immune regulation and other processes.Tocilizumab, a humanized interleukin-6 receptor (IL-6R) monoclonal antibody, can competitively binds toIL-6 receptor, which blocks the biological effects of endogenous IL-6. For JIA associated uveitis (JIAU)patients who failed glucocorticoid, methotrexate and 2 monoclonal antibody TNFi at above-standard doseand/or frequency, tocilizumab becomes a new treatment option for JIAU. This paper mainly summarizesthe mechanism, application and safety of tocilizumab in the treatment of JIAU in order to provide referencefor clinical decision-making.