Left Atrial Appendage Occlusion for The Unmet Clinical Needs of Stroke Prevention in Nonvalvular Atrial Fibrillation |
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| Affiliation: | 1. Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN;2. Division of Cardiology, West Virginia University School of Medicine, Morgantown;3. Department of Medicine, Division of Cardiology, Helmsley Electrophysiology Center, Mount Sinai Medical Center, New York, NY |
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| Abstract: | Oral anticoagulation is the dominant strategy for stroke prevention in patients with nonvalvular atrial fibrillation. However, lifelong oral anticoagulation is associated with major issues including inappropriate dosing, nonadherence, and adverse effects. Therefore, efforts have been made to develop site-specific therapy aimed to occlude the left atrial appendage, the anatomical site accountable for more than 90% of nonvalvular atrial fibrillation–related ischemic strokes. This review focuses on the growing literature to put into perspective the risk-balance ratio of left atrial appendage occlusion. |
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