Transdermal Delivery of Sumatriptan Succinate Using Iontophoresis and Dissolving Microneedles |
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| Affiliation: | 1. Harvard Radiation Oncology Program, Boston, MA 02114, USA;2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;3. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;4. Division of Surgical Oncology, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;5. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;6. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA;1. School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA;2. Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA;3. Emory University School of Medicine, Atlanta, GA 30322, USA;4. Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA |
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| Abstract: | This study focuses on the in vitro transdermal transport of sumatriptan succinate using combined iontophoresis and dissolving polymeric microneedle arrays. Permeation experiments were performed to evaluate the effects of formulation parameters on drug release from polyvinylpyrrolidone systems under mild electrical current (≤500 μA/cm2). The preparations consisted of hydrophilic, positively charged molecules encapsulated in a water-soluble and biocompatible polymeric material. Current densities of 100, 300, and 500 μA/cm2 were applied during a 6-h period using silver/silver chloride electrodes. The circular array consisted of 600 needles and occupied a 0.785 cm2 area. Tests, carried out with Franz diffusion cells and skin of Göttingen minipigs, showed that small decreases in the polymer concentration led to negligible lag times and marked increases in the cumulative amount of drug permeated in 6 h (Q6h) and in the flux (Jss). At 500 μA/cm2, Q6h and Jss nearly doubled for a microneedle loaded with 5% (w/w) sumatriptan and 20% (w/w) PVP (lag time = 0 min; Q6h = 2888 μg/cm2; Jss = 490 μg/cm2/h) relative to a system loaded with 5% (w/w) drug and 30% (w/w) PVP (lag time = 36 min; Q6h = 1437 μg/cm2; Jss = 266 μg/cm2/h). |
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| Keywords: | controlled release dissolution drug delivery system iontophoresis microarray(s) transdermal |
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