Nrf2对口腔鳞癌患者TPF诱导化疗效果的影响

目的: 检测核转录相关因子2（Nrf2）在口腔鳞癌组织中的表达,探讨其对TPF诱导化疗效果的影响。方法: 选择65例接受TPF诱导化疗的口腔鳞癌患者,采用免疫组织化学方法检测患者活检肿瘤标本中Nrf2的表达,分析Nrf2表达与患者基线资料及预后的关系。采用SPSS 23.0软件包对数据进行统计学分析。结果: 生存分析发现,口腔鳞癌患者Nrf2表达与TPF诱导化疗预后显著相关,Nrf2低表达者较高表达者具有更好的总生存率、无疾病生存率、局部无复发生存率、无远处转移生存率。单因素及多因素Cox风险模型分析发现,Nrf2是口腔鳞癌患者TPF化疗的独立预后风险因素。结论: Nrf2表达与口鳞癌患者TPF诱导化疗疗效相关,Nrf2低表达患者预后更好,Nrf2可作为预测口腔鳞癌患者TPF诱导化疗效果的生物标志物。

Effect of Nrf2 on TPF induced chemotherapy for oral squamous cell carcinoma

PURPOSE: To examine the expression of nuclear factor erythroid-2 related factor (Nrf2) in oral squamous cell carcinoma (OSCC) and investigate the effect of Nrf2 on TPF induced chemotherapy. METHODS: A total of 65 patients with OSCC who received TPF chemotherapy were selected. Nrf2 expression in the biopsy specimens before treatment was examined by immunohistochemistry. The correlations between Nrf2 expression and clinical factors and clinical response to TPF induced chemotherapy were analyzed. SPSS 23.0 software package was used for data analysis. RESULTS: Survival analysis showed that Nrf2 expression was significantly correlated with the prognosis of TPF induced chemotherapy in OSCC patients. Patients with higher Nrf2 expression had better overall survival, disease-free survival, local relapse-free survival and distant metastasis free survival. Univariate and multivariate Cox analysis showed that Nrf2 was an independent prognostic risk factor for TPF chemotherapy in OSCC patients. CONCLUSIONS: The expression of Nrf2 is correlated with the efficacy of TPF induced chemotherapy in OSCC patients. Patients with low Nrf2 have a better prognosis, and Nrf2 can be used as a biomarker to predict the efficacy of TPF induced chemotherapy in OSCC patients