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Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation
Affiliation:1. Otto Loewi Research Center, Pharmacology Section, Medical University of Graz, and BioTechMed, Graz, Austria;2. Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden;5. Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden;7. Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;9. Department of Clinical Science, Intervention and Technology, CLINTEC, Karolinska Institutet, Stockholm, Sweden;3. Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institutet, and Clinical Immunology and transfusion medicine, Karolinska University Hospital, Stockholm, Sweden;4. Institute of Clinical Pharmacology, Goethe-University Frankfurt, Pharmazentrum Frankfurt/ZAFES, Frankfurt, Germany;6. Department of Medical Sciences, Uppsala University, Uppsala, Sweden;8. Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project group Translational Medicine & Pharmacology TMP, Frankfurt, Germany;10. Department of Surgical Science, Uppsala University, Uppsala, Sweden;11. Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden;1. Department of Medicine, Harvard Medical School, Boston, Mass;2. Division of Rheumatology, Immunology, and Allergy, Brigham and Women''s Hospital, Boston, Mass;1. Department of Medicine, Harvard Medical School, Boston, Mass;2. Department of Surgery, Harvard Medical School, Boston, Mass;3. Division of Rheumatology, Immunology, and Allergy, Brigham and Women''s Hospital, Boston, Mass;4. Division of Otolaryngology, Brigham and Women''s Hospital, Boston, Mass;5. Division of Pulmonary Medicine, Brigham and Women''s Hospital, Boston, Mass;1. Department of Medicine, University of California, La Jolla, Calif;2. Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, Calif;1. Center for Infectious Medicine, Department of Medicine, Huddinge, Karolinska Institutet, 14186 Stockholm, Sweden;2. Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, 8010 Graz, Austria;1. Department of Otolaryngology, QiLu Hospital of Shandong University, Jinan, China;2. Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, Va;3. Carter Immunology Center, University of Virginia Health System, Charlottesville, Va;4. Department of Medicine, University of Virginia Health System, Charlottesville, Va;5. Department of Microbiology, University of Virginia Health System, Charlottesville, Va;6. Department of Otolaryngology–Head and Neck Surgery, University of Virginia Health System, Charlottesville, Va;1. Department of Medicine, University of California San Diego, La Jolla, Calif;2. Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children''s Hospital Research Institute, Little Rock, Ark
Abstract:
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  • Keywords:Group 2 innate lymphoid cells  allergy  CBMC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0035"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Cord blood–derived mast cell  CRTH2"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0045"  },"  $$"  :[{"  #name"  :"  text"  ,"  $$"  :[{"  #name"  :"  __text__"  ,"  _"  :"  Chemoattractant receptor–homologous molecule expressed on T"  },{"  #name"  :"  inf"  ,"  $"  :{"  loc"  :"  post"  },"  _"  :"  H"  },{"  #name"  :"  __text__"  ,"  _"  :"  2 cells  DP1"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0065"  },"  $$"  :[{"  #name"  :"  text"  ,"  $$"  :[{"  #name"  :"  __text__"  ,"  _"  :"  Prostaglandin D"  },{"  #name"  :"  inf"  ,"  $"  :{"  loc"  :"  post"  },"  _"  :"  2"  },{"  #name"  :"  __text__"  ,"  _"  :"   receptor 1  HPGD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0085"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  15-Hydroxyprostaglandin dehydrogenase  HPGDS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0095"  },"  $$"  :[{"  #name"  :"  text"  ,"  $$"  :[{"  #name"  :"  __text__"  ,"  _"  :"  Hematopoietic prostaglandin D"  },{"  #name"  :"  inf"  ,"  $"  :{"  loc"  :"  post"  },"  _"  :"  2"  },{"  #name"  :"  __text__"  ,"  _"  :"   synthase  ILC2"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0105"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Group 2 innate lymphoid cell  IMDM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0115"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Iscove modified Dulbecco medium  LC-MS/MS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0125"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Liquid chromatography–tandem mass spectrometry  LPGDS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0135"  },"  $$"  :[{"  #name"  :"  text"  ,"  $$"  :[{"  #name"  :"  __text__"  ,"  _"  :"  Lipocalin prostaglandin D"  },{"  #name"  :"  inf"  ,"  $"  :{"  loc"  :"  post"  },"  _"  :"  2"  },{"  #name"  :"  __text__"  ,"  _"  :"   synthase  LT"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0145"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Leukotriene  NHS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0155"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Normal human serum  PE"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0165"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Phycoerythrin  Prostaglandin  PPAR-γ"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0185"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Peroxisome proliferator–activated receptor γ  RT-qPCR"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0195"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Quantitative RT-PCR  TSLP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0205"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Thymic stromal lymphopoietin
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