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Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation

Institution:	1. Otto Loewi Research Center, Pharmacology Section, Medical University of Graz, and BioTechMed, Graz, Austria;2. Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden;5. Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden;7. Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;9. Department of Clinical Science, Intervention and Technology, CLINTEC, Karolinska Institutet, Stockholm, Sweden;3. Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institutet, and Clinical Immunology and transfusion medicine, Karolinska University Hospital, Stockholm, Sweden;4. Institute of Clinical Pharmacology, Goethe-University Frankfurt, Pharmazentrum Frankfurt/ZAFES, Frankfurt, Germany;6. Department of Medical Sciences, Uppsala University, Uppsala, Sweden;8. Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project group Translational Medicine & Pharmacology TMP, Frankfurt, Germany;10. Department of Surgical Science, Uppsala University, Uppsala, Sweden;11. Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden;1. Department of Medicine, Harvard Medical School, Boston, Mass;2. Division of Rheumatology, Immunology, and Allergy, Brigham and Women''s Hospital, Boston, Mass;1. Department of Medicine, Harvard Medical School, Boston, Mass;2. Department of Surgery, Harvard Medical School, Boston, Mass;3. Division of Rheumatology, Immunology, and Allergy, Brigham and Women''s Hospital, Boston, Mass;4. Division of Otolaryngology, Brigham and Women''s Hospital, Boston, Mass;5. Division of Pulmonary Medicine, Brigham and Women''s Hospital, Boston, Mass;1. Department of Medicine, University of California, La Jolla, Calif;2. Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, Calif;1. Center for Infectious Medicine, Department of Medicine, Huddinge, Karolinska Institutet, 14186 Stockholm, Sweden;2. Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, 8010 Graz, Austria;1. Department of Otolaryngology, QiLu Hospital of Shandong University, Jinan, China;2. Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, Va;3. Carter Immunology Center, University of Virginia Health System, Charlottesville, Va;4. Department of Medicine, University of Virginia Health System, Charlottesville, Va;5. Department of Microbiology, University of Virginia Health System, Charlottesville, Va;6. Department of Otolaryngology–Head and Neck Surgery, University of Virginia Health System, Charlottesville, Va;1. Department of Medicine, University of California San Diego, La Jolla, Calif;2. Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children''s Hospital Research Institute, Little Rock, Ark

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Keywords:	Group 2 innate lymphoid cells allergy CBMC"} {"#name":"keyword" "$":{"id":"kwrd0035"} "$$":[{"#name":"text" "_":"Cord blood–derived mast cell CRTH2"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "$$":[{"#name":"__text__" "_":"Chemoattractant receptor–homologous molecule expressed on T"} {"#name":"inf" "$":{"loc":"post"} "_":"H"} {"#name":"__text__" "_":"2 cells DP1"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "$$":[{"#name":"__text__" "_":"Prostaglandin D"} {"#name":"inf" "$":{"loc":"post"} "_":"2"} {"#name":"__text__" "_":" receptor 1 HPGD"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"15-Hydroxyprostaglandin dehydrogenase HPGDS"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "$$":[{"#name":"__text__" "_":"Hematopoietic prostaglandin D"} {"#name":"inf" "$":{"loc":"post"} "_":"2"} {"#name":"__text__" "_":" synthase ILC2"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"Group 2 innate lymphoid cell IMDM"} {"#name":"keyword" "$":{"id":"kwrd0115"} "$$":[{"#name":"text" "_":"Iscove modified Dulbecco medium LC-MS/MS"} {"#name":"keyword" "$":{"id":"kwrd0125"} "$$":[{"#name":"text" "_":"Liquid chromatography–tandem mass spectrometry LPGDS"} {"#name":"keyword" "$":{"id":"kwrd0135"} "$$":[{"#name":"text" "$$":[{"#name":"__text__" "_":"Lipocalin prostaglandin D"} {"#name":"inf" "$":{"loc":"post"} "_":"2"} {"#name":"__text__" "_":" synthase LT"} {"#name":"keyword" "$":{"id":"kwrd0145"} "$$":[{"#name":"text" "_":"Leukotriene NHS"} {"#name":"keyword" "$":{"id":"kwrd0155"} "$$":[{"#name":"text" "_":"Normal human serum PE"} {"#name":"keyword" "$":{"id":"kwrd0165"} "$$":[{"#name":"text" "_":"Phycoerythrin Prostaglandin PPAR-γ"} {"#name":"keyword" "$":{"id":"kwrd0185"} "$$":[{"#name":"text" "_":"Peroxisome proliferator–activated receptor γ RT-qPCR"} {"#name":"keyword" "$":{"id":"kwrd0195"} "$$":[{"#name":"text" "_":"Quantitative RT-PCR TSLP"} {"#name":"keyword" "$":{"id":"kwrd0205"} "$$":[{"#name":"text" "_":"Thymic stromal lymphopoietin
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