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Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid
Institution:1. Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland;2. Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland;3. Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan;4. Immunology and Allergy, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden;5. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich and University of Zurich, Zurich, Switzerland;6. Department of Immunology, Faculty of Health Science, Kyorin University, Tokyo, Japan;7. Functional Genomics Center Zurich, ETH Zurich/University of Zurich, Zurich, Switzerland;8. Animal Research Center, Tokyo Medical University, Tokyo, Japan;9. Department of Medicine and Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland;10. Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan;11. RIKEN Center for Integrative Medical Science (IMS), Kanagawa, Japan;12. Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;13. Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Saitama, Japan;14. Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden;1. Department of Medicine, Division of Allergy & Immunology, and the Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo;2. Department of Medicine, University of Colorado Denver, School of Medicine, Denver, Colo;3. Department of Cytobiology and Proteomics, Medical University of Lodz, Lodz, Poland;1. Division of Respirology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada;2. Guangzhou Institute of Respiratory Diseases, Guangzhou Medical University, Guangzhou, China;3. Institut universitaire de cardiologie et de pneumologie de Québec, Quebec City, Quebec, Canada;4. Division of Pneumologie, University of Montreal, Montreal, Quebec, Canada;5. Meakins-Christie Laboratories, Research Institute of the McGill University Health Center, Hamilton, Ontario, Canada;1. Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada;2. Genetics Graduate Program, College for Interdisciplinary Studies, University of British Columbia, Vancouver, British Columbia V6T 1Z2, Canada;3. Medical Research Council, Laboratory of Molecular Biology, Cambridge, Cambridgeshire CB2 0QH, UK;4. Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada;5. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada;1. CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China;2. University of Chinese Academy of Sciences, 100049 Beijing, China;3. Department of Gastrointestinal Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041 Chengdu, China;4. Key Laboratory of RNA Biology of CAS, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China;5. The First Affiliated Hospital, Biomedical Translation Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, 510632 Guangzhou, China;6. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China;1. Royal National ENT Hospital, London, UK;2. Royal Brompton Hospital, London, UK;1. Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, and the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom;2. Section of Immunobiology, Division of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom
Abstract:
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  • Keywords:Regulatory innate lymphoid cells  Group 2 innate lymphoid cells  retinoic acid  IL-33  asthma  chronic rhinosinusitis with nasal polyps  cytotoxic T lymphocyte–associated protein 4  ALI"}  {"#name":"keyword"  "$":{"id":"kwrd0050"}  "$$":[{"#name":"text"  "_":"Air-liquid interface  BALF"}  {"#name":"keyword"  "$":{"id":"kwrd0060"}  "$$":[{"#name":"text"  "_":"Bronchoalveolar lavage fluid  CFSE"}  {"#name":"keyword"  "$":{"id":"kwrd0070"}  "$$":[{"#name":"text"  "_":"Carboxyfluorescein succinimidyl ester  CRSwNP"}  {"#name":"keyword"  "$":{"id":"kwrd0080"}  "$$":[{"#name":"text"  "_":"Chronic rhinosinusitis with nasal polyps  CRTH2"}  {"#name":"keyword"  "$":{"id":"kwrd0090"}  "$$":[{"#name":"text"  "$$":[{"#name":"__text__"  "_":"Chemoattractant receptor–homologous molecule on T"}  {"#name":"inf"  "$":{"loc":"post"}  "_":"H"}  {"#name":"__text__"  "_":"2 cells  CTLA-4"}  {"#name":"keyword"  "$":{"id":"kwrd0100"}  "$$":[{"#name":"text"  "_":"Cytotoxic T lymphocyte–associated protein 4  DAPI"}  {"#name":"keyword"  "$":{"id":"kwrd0110"}  "$$":[{"#name":"text"  "_":"4′-6-Diamidino-2-phenylindole dihydrochloride  Foxp3"}  {"#name":"keyword"  "$":{"id":"kwrd0120"}  "$$":[{"#name":"text"  "_":"Forkhead box P3  HDM"}  {"#name":"keyword"  "$":{"id":"kwrd0130"}  "$$":[{"#name":"text"  "_":"House dust mite  Id3"}  {"#name":"keyword"  "$":{"id":"kwrd0140"}  "$$":[{"#name":"text"  "_":"Inhibitor of DNA binding 3  ILC"}  {"#name":"keyword"  "$":{"id":"kwrd0150"}  "$$":[{"#name":"text"  "_":"Innate lymphoid cell  ILC1"}  {"#name":"keyword"  "$":{"id":"kwrd0160"}  "$$":[{"#name":"text"  "_":"Group 1 innate lymphoid cells  ILC2"}  {"#name":"keyword"  "$":{"id":"kwrd0170"}  "$$":[{"#name":"text"  "_":"Group 2 innate lymphoid cell  IL-10–producing innate lymphoid cell  ILC3"}  {"#name":"keyword"  "$":{"id":"kwrd0190"}  "$$":[{"#name":"text"  "_":"Group 3 innate lymphoid cell  ILCreg"}  {"#name":"keyword"  "$":{"id":"kwrd0200"}  "$$":[{"#name":"text"  "_":"Regulatory innate lymphoid cell  IL-10R"}  {"#name":"keyword"  "$":{"id":"kwrd0210"}  "$$":[{"#name":"text"  "_":"IL-10 receptor  KLRG1"}  {"#name":"keyword"  "$":{"id":"kwrd0310"}  "$$":[{"#name":"text"  "_":"Killer cell lectin-like receptor G1  MMP-7"}  {"#name":"keyword"  "$":{"id":"kwrd0220"}  "$$":[{"#name":"text"  "_":"Matrix metalloproteinase 7  PE"}  {"#name":"keyword"  "$":{"id":"kwrd0230"}  "$$":[{"#name":"text"  "_":"Phycoerythrin  PMA"}  {"#name":"keyword"  "$":{"id":"kwrd0240"}  "$$":[{"#name":"text"  "_":"Phorbol 12-myristate 13-acetate  RA"}  {"#name":"keyword"  "$":{"id":"kwrd0250"}  "$$":[{"#name":"text"  "_":"Retinoic acid  RALDH"}  {"#name":"keyword"  "$":{"id":"kwrd0260"}  "$$":[{"#name":"text"  "_":"Retinaldehyde dehydrogenase  RAR"}  {"#name":"keyword"  "$":{"id":"kwrd0270"}  "$$":[{"#name":"text"  "_":"Retinoic acid receptor  RNA-seq"}  {"#name":"keyword"  "$":{"id":"kwrd0280"}  "$$":[{"#name":"text"  "_":"RNA sequencing  TCR"}  {"#name":"keyword"  "$":{"id":"kwrd0290"}  "$$":[{"#name":"text"  "_":"T-cell receptor  Treg"}  {"#name":"keyword"  "$":{"id":"kwrd0300"}  "$$":[{"#name":"text"  "_":"Regulatory T
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