南京市初治肺结核患者成功治疗后复发及影响因素分析

Objective To analyze the recurrence and influencing factors of the new pulmonary tuberculosis (TB) cases after successful treatment in Nanjing, and provide evidence for reducing TB recurrence. Methods With retrospective cohort study method, the data of new TB cases which were successful treated during 2011-2019 derived from the TB Information Management System, then the recurrence condition were collected from 2011 to 2020. The recurrence rate was estimated by using life-table method, and the influencing factors were analyzed by a Cox proportional hazard regression model. Results Among 19 452 TB patients, 484 cases had recurred by the end of 2020, with a recurrence rate density of 0.52/100 person-years. The median recurrence interval was 1.66（0.67，3.18） years. 73.14% had recurrence within 3 years and 91.53% had recurrence within 5 years. Multivariate Cox proportional hazard regression model showed that men (HR=1.517, 95%CI: 1.219-1.889), aged ≥40 years old (HR=2.360, 95%CI:1.254-4.439), etiology positive (HR=2.028, 95%CI:1.682-2.444), lung cavity before treatment (HR=1.464, 95%CI:1.198-1.789) and complicated with diabetes mellitus (HR=5.860, 95%CI:3.557-9.653) were the major risk factors for tuberculosis recurrence. Conclusions The recurrence rate of the new TB patients was low in Nanjing, however, affirmative measures should be taken for high-risk patients to reduce recurrence. Early identification, targeted intervention and follow-up management should be strengthened for patients who were male, over 40 years old, etiology positive, with lung cavity before treatment and complicated with diabetes mellitus. © 2022 Editorial Office of Chinese Journal of Schistosomiasis Control. All rights reserved.

Recurrence and influencing factors of the new pulmonary tuberculosis after successful treatment in Nanjing

Objective To analyze the recurrence and influencing factors of the new pulmonary tuberculosis (TB) cases after successful treatment in Nanjing, and provide evidence for reducing TB recurrence. Methods With retrospective cohort study method, the data of new TB cases which were successful treated during 2011-2019 derived from the TB Information Management System, then the recurrence condition were collected from 2011 to 2020. The recurrence rate was estimated by using life-table method, and the influencing factors were analyzed by a Cox proportional hazard regression model. Results Among 19 452 TB patients, 484 cases had recurred by the end of 2020, with a recurrence rate density of 0.52/100 person-years. The median recurrence interval was 1.66（0.67,3.18） years. 73.14% had recurrence within 3 years and 91.53% had recurrence within 5 years. Multivariate Cox proportional hazard regression model showed that men (HR=1.517, 95%CI:1.219-1.889), aged ≥40 years old (HR=2.360, 95%CI:1.254-4.439), etiology positive (HR=2.028, 95%CI:1.682-2.444), lung cavity before treatment (HR=1.464, 95%CI:1.198-1.789) and complicated with diabetes mellitus (HR=5.860, 95%CI:3.557-9.653) were the major risk factors for tuberculosis recurrence. Conclusions The recurrence rate of the new TB patients was low in Nanjing, however, affirmative measures should be taken for high-risk patients to reduce recurrence. Early identification, targeted intervention and follow-up management should be strengthened for patients who were male, over 40 years old, etiology positive, with lung cavity before treatment and complicated with diabetes mellitus.