Association Between Genetic Variations of Vascular Endothelial Growth Factor Receptor 2 and Glioma in the Chinese Han Population |
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Authors: | Hongyan Chen Weimin Wang Zhao Xingjie Xiao Song Weiwei Fan Zhou Keke Gong Chen Yao Zhao Ying Mao Daru Lu |
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Institution: | State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China. |
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Abstract: | Tumor angiogenesis, which is an important step in the development of cancer, is directly regulated by vascular endothelial growth factor receptor 2 (VEGFR-2). In this study, we examined the association of five potentially functional VEGFR-2 polymorphisms with glioma risk in a Chinese Han population. Three SNPs, rs2071559, rs7667298 and rs2305948, showed a statistically significant increased association with the risk of glioma (P?=?0.006, 0.005, and 0.012, respectively). Both haplotype and diplotype analyses consistently revealed that subjects carrying two copies of the haplotype "CGT" had a 42% reduced glioma risk compared with their respective noncarriers. Our findings suggested that VEGFR-2 gene variants might contribute to glioma susceptibility. |
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