氟比洛芬酯对胸腔镜手术患者全麻苏醒期机体应激反应的影响

目的：研究氟比洛芬酯对胸腔镜手术患者全麻苏醒期机体应激反应的影响及其临床效果。方法50例ASA I-II级行择期胸腔镜手术患者随机分为氟比洛芬酯组（E组）和对照组（C组）,每组25例。 E组在麻醉诱导前10min经静脉给予氟比洛芬酯50mg,手术结束前30min再给予氟比洛芬酯50mg；而C组不给予氟比洛芬酯。记录两组患者手术结束时（T1）和气管导管拔管时（T2）两个时点平均动脉压（MAP）、心率（HR）和脉搏血氧饱和度（Spo2）。同时点抽取静脉血5mL检测T 1和T 2两个时点的血糖和去甲肾上腺素的水平。结果与C组相比,E组患者T 1和T 2两时点的MAP和HR明显降低（P〈0．01）；E组患者在T1、T2时点血糖降低（P〈0．05）；T2时点去甲肾上腺素明显降低（P〈0．01）。结论氟比洛芬酯能明显抑制胸腔镜手术患者全麻苏醒期的应激反应,有利于血流动力学的稳定。

Effect of Flurbiprofen Axetii Injection on Stress Response during Recovery Period after General Anesthesia in Thoracoscope Surgery Patients

Objective To study the effect of Flurbiprofen Axetil Injection on stress response during recovery period after general anesthesia in Thoracoscope surgery patients and its clinical effects. Methods 50 patients ASA Ⅰ-Ⅱ for elective brain tumors surgery were randomized clivided into Flurbiprofen Axetil group （ E group） and control group （ C group） ,each group con-sisting of 25 cases. E group were administrated Flurbiprofen Axetil Injection 50mg before induction and another 50mg 30 minutes before the end of surgery, while C group were not given Flurbiprofen Axetil Injection. Both groups were recorded the end of surgery （T1） and the endotracheal tube extubation （T2）,and two point time mean arterial pressure （MAP）, heart rate （HR） and pulse oxygen saturation （Spo2）. The blood glucose and norepinephrine levels were detected at T1 and T2. Results Compared with the C group, the MAP and HR in E group were significantly lower at T1 and T2 （P〈0. 01）;The blood glucose decreased at T1 and T2 （P〈0. 05）;The norepinephrine activity were significantly lower at T2（P〈0. 01）. Conclusion Flurbiprofen Axetil Injection can inhibit stress response during the recovery from general anesthesia in Thoracoscope surgery patients, and it is beneficial to hemodynamic stability.