影响冻融胚胎移植妊娠结局的相关因素分析

目的:探讨影响冻融胚胎移植(FET)妊娠结局的相关因素。方法:回顾性分析324个周期行FET患者的临床资料,分析患者年龄、体质量指数(BMI)、移植日子宫内膜厚度、内膜准备方案、移植胚胎数等相关因素对FET妊娠结局的影响。结果:324个周期共解冻胚胎727个,复苏成活720个(99.0%),临床妊娠144例(44.4%),胚胎植入196例(27.2%)。其中自然内膜准备周期组和激素替代内膜准备周期组患者年龄、不孕年限、基础卵泡刺激素(bFSH)、基础黄体生成素(bLH)、基础雌二醇(bE2)、复苏胚胎数、移植胚胎数、移植日子宫内膜厚度、胚胎种植率及临床妊娠率组间均无统计学差异(P0.05)。年龄≤35岁组的临床妊娠率高于年龄35岁组,差异有统计学意义(P0.05);BMI≥24.0 kg/m2的肥胖组临床妊娠率与正常体质量(BMI=18.5~23.9 kg/m2)组无统计学差异(P0.05);移植日子宫内膜厚度≥7 mm组的临床妊娠率高于移植日子宫内膜厚度7 mm组,但差异无统计学意义(P0.05);各移植胚胎数组间临床妊娠率无统计学差异(P0.05)。结论:年龄是影响FET临床结局的重要因素,内膜准备方案、BMI、移植日内膜厚度、移植胚胎数对冻融胚胎移植临床结局无影响。

Influence of Related Factors on the Pregnancy Outcome of Frozen-thawed Embryo Transfer

Objective： To investigate the influence of related factors on the pregnancy outcome of frozenthawed embryo transfer （FET）. Methods： The clinical data of 324 cycles of FET were retrospectively analyzed. Patients＇ age, body mass index （BMI）, endometrial thickness on the day of transplantation, endometrial preparation protocol, the number of embryo transferred were compared. Results： A total of 727 embryos were thawed in 324 transfer cycles, 720 （99.0%） resuscitated, 144 cases of clinical pregnancy （44.4%）, embryo implantation in 196 cases （27.2%）. There were no obvious differences in the patients＇ age, infertility duration, basal follicle stimulating homione （FSH）, basal luteinizing hormone （bLH）, basal estradiol （bE2）, embryos resuscitated, embryos transferred, endometrial thickness on the day of transplantation, embryoS impiamation rate, clinical pregnancy rate between nature cycle and hormone replacement cycle （P〉0.05）. Clinical pregnancy rate of patients who were less than 35 years old were higher than that of the older than 35 years old, the difference was statistically significant （P〈0.05）. The difference was not statistically significant in implantantion rates and clinical pregnancy rates between the obesity group and the nomal weight group （P〉0.05）. Clinical pregnancy rate of endometrial thickness ≥ 7 mm on the day of transplantation was higher than that of endometrial thickness 〈7 mm on the day of transplantation, but the difference was not statistically significant （P〉0.05）; the difference was not statistically significant between transferred 3 embryos and transferred 2 embryos. Conclusion： The patients＇ age is an important affecting factor on the outcome of FET, but endometrial preparation protocols, BMI, endometrial thickness on the day of transplantation, the number of embryos transferred did not affect the clinical outcome.