| 难治性精神分裂症的立体定向手术治疗——术后一年随访结果 |
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| 引用本文： | 王一芳,许爱刚,王正伟,朱浩,耿晓增,石海明,赵伯成.难治性精神分裂症的立体定向手术治疗——术后一年随访结果[J].立体定向和功能性神经外科杂志,2006,19(5):263-266. |
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| 作者姓名： | 王一芳 许爱刚 王正伟 朱浩 耿晓增 石海明 赵伯成 |
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| 作者单位： | 1. 210002,南京,南京解放军第454医院神经外科
2. 南京医科大学第一附属医院神经外科 |
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| 摘 要： | 目的探讨立体定向手术治疗难治性精神分裂症的临床疗效。方法对251例难治性精神分裂症患者,采用CT定位立体定向双侧杏仁核、内囊前肢、扣带回等多靶点组合毁损治疗,术中用电阻值和微电极电生理验证靶点,其中17例患者因首次手术后3~6个月疗效不佳而接受二次手术。术后1年由精神科医生对治疗效果进行评定。结果251例患者中,恢复13例、显著进步200例、进步29例、无变化9例,无严重并发症发生。结论CT导向立体定向多靶点组合毁损术安全,是难治性精神分裂症的有效治疗方法之一。
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| 关 键 词： | 精神分裂症 难治性 立体定向术 |
| 文章编号： | 1008-2425（2006）05-0263-04 |
| 收稿时间： | 2006-02-08 |
| 修稿时间： | 2006年2月8日 |
Treatment of intractable schizophrenia with stereotactic surgery |
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| Wang Yifang, Xu Aigang ,Wang Zhengwei ,et al..Treatment of intractable schizophrenia with stereotactic surgery[J].Chinese Journal of Stereotactic and Functional Neurosurgery,2006,19(5):263-266. |
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| Authors: | Wang Yifang Xu Aigang Wang Zhengwei |
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| Institution: | Department of neurosurgery, No. 454 Hospital of PLA, Nanjing 210002 |
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| Abstract: | Objective To study the clinical effect of stereotactic surgery in patients with intractability schizophrenia.Methods 251 cases of intractability schizophrenia were treated by CT guide stereotactic bilateral multiple nuclei lesion.The target of lesion was determined under CT directly and was verified by microelectrode and electric impedance.17 patients received twice multiple nuclei lesion in 3 to 6 months because of the first operation was ineffective.The therapeutic effects were evaluated by psychiatrist one year later.Results In the 251 cases underwent operation,13 patients recovered,200 patients had significant improvement,29 patients had improvement and 9 patients had no change.No serious complication and sequela taken occurrenced.Conclusion CT guide stereotactic bilateral multiple nuclei lesion is a safe and effective method for treating some medically intractable schizophrenia. |
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| Keywords: | Schizophrenia Intractability Stereotactic surgery |
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