| iNOS在大鼠正畸牙齿移动过程中牙周组织中的表达 |
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| 引用本文： | 李伟宏,吴立鹏,赵刚. iNOS在大鼠正畸牙齿移动过程中牙周组织中的表达[J]. 黑龙江医药科学, 2005, 28(5): 24-25 |
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| 作者姓名： | 李伟宏 吴立鹏 赵刚 |
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| 作者单位： | 温州医学院附属口腔医院正畸科 浙江温州325000(李伟宏)，佳木斯大学附属口腔医院正畸科 黑龙江佳木斯154002(吴立鹏)，佳木斯大学附属口腔医院正畸科 黑龙江佳木斯154002(赵刚) |
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| 摘 要： | 目的:观察诱导型一氧化氮合酶(induc ib le n itric ox ide syn thase,iNO S)在大鼠正畸牙齿移动过程中牙周组织改建过程中的表达,探讨NO/iNO S在正畸牙齿移动中的作用机制。方法:56只雄性W istar大鼠随机分为8组。正畸加力1、3、5、7、14、21、28d组和对照组分别进行HE和免疫组化染色、图像分析。结果:正畸加力3d后,牙周组织细胞iNO S表达增强,7d i-NO S表达达到高峰(P<0.01),以后iNO S表达下降。结论:NO/iNO S参与了正畸牙周组织改建过程,NO/iNO S可能参与了成骨过程。
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| 关 键 词： | 诱导型一氧化氮合酶 免疫组织化学 牙移动 |
| 文章编号： | 1008-0104-(2005)05-0024-02 |
| 修稿时间： | 2005-04-23 |
iNOS expression in the periodontal tissues in tooth movement in rat |
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| LI Wei-hong,WU Li-peng,ZHAO Gang_. iNOS expression in the periodontal tissues in tooth movement in rat[J]. Heilongjiang Medicine and Pharmacy, 2005, 28(5): 24-25 |
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| Authors: | LI Wei-hong WU Li-peng ZHAO Gang_ |
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| Affiliation: | LI Wei-hong~1,WU Li-peng~1,ZHAO Gang_2 |
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| Abstract: | Objective: To observe the expression of inducible nitric oxide synthase(iNOS) in the orthodontic periodontal tissue remodeling,and study the role of NO/iNOS in the tooth movement in rats.Methods: Fifty-six male Wistar rats were randomly divided into 8 groups.Orthodontic appliance was placed between the maxillary right firstmolar and maxillary central incisors of rat.Immunohistochemistry and image analyses were performed at 0,1,3,5,7,14,21,28 days after orthodontic force application.Results: The expression of iNOS showed weak immunoreactivities in normal periodotium.3 days after the tooth movement,the immunoreactivities of iNOS were increased and at 7 days,reached the maximum.Conclusion: NO/iNOS participate in the orthodontic periodontal tissue remodeling in the tooth movement and NO/iNOS can promote the bone formation. |
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| Keywords: | inducible nitric oxide synthase immunohistochemistry tooth movement |
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