Neurophysiological effects of buspirone and isapirone in the hippocampus: comparison with 5-hydroxytryptamine |
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| Authors: | M J Rowan R Anwyl |
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| Affiliation: | 1. Department of Pharmacology and Therapeutics, Ireland;1. Department of Physiology, Faculty of Health Sciences, Trinity College, Dublin 22, Ireland;1. Department of Neurology, University Hospital Schleswig-Holstein, Kiel, University of Kiel, Germany;2. Institute of Psychology, Martin-Luther-University Halle-Wittenberg, Halle, Germany;3. Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Germany;1. Department of Psychology, Box 413, University of Wisconsin–Milwaukee, Milwaukee, WI 53201, USA;1. Neuroscience Program, Skidmore College, 815 N. Broadway, Saratoga Springs, NY 12866, United States;2. Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, United States;3. Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, United States;4. Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States;1. Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea;2. Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea;3. Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, 06974, Republic of Korea;4. Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea;5. Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, Aichi, 470-1192, Japan;6. Aino University, Ibaraki, 576-0012, Japan;7. Japanese Drug Organization of Appropriate and Research, Nagoya, 468-0069, Japan |
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| Abstract: | The neurophysiological effects of two novel anxiolytic compounds, buspirone and isapirone (TVX Q 7821), were compared with those of 5-hydroxytryptamine (5-HT) on the population spike in the CA1 region of the rat hippocampal slice. Micromolar concentrations of the two drugs mimicked the inhibitory effect of 5-HT but unlike 5-HT they did not produce any significant excitation. In slices in which 5-HT was purely excitatory, there was a marked reduction in the inhibitory response to these agents. The effect of isapirone was antagonised by spiperone. These results suggest that buspirone and isapirone are agonists for 5-HT1A receptors in the hippocampus. |
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