急性脑梗死患者脑动脉狭窄与危险因素的相关性

目的探讨急性脑梗死患者脑动脉狭窄与危险因素的相关性。方法对230例住院急性脑梗死患者行头颅MRA检查,根据MRA所提示脑动脉狭窄的检查结果分为狭窄组（n=125）和对照组（n=105）。调查患者年龄、性别、糖尿病史、高血压病史、吸烟等危险因素,用全自动血生化分析仪测量患者的血生化指标。结果狭窄组和对照组在年龄、性别、高血压病史、吸烟史方面差异无统计学意义,两组血清胆固醇、甘油三脂、低密度脂蛋白胆固醇、脂蛋白a、胆红素、尿酸水平差异无统计学意义（P〉0.05）;糖尿病史狭窄组高于对照组,血糖水平狭窄组高于对照组,而高密度脂蛋白胆固醇水平狭窄组低于对照组（P〈0.05）。Logistic多元回归分析高密度脂蛋白胆固醇降低是脑动脉狭窄的独立危险因素。结论在急性脑梗死脑动脉狭窄的发生发展中,血清糖及高密度脂蛋白胆固醇起着非常重要的作用。

Relation between cerebral arterial stenosis and risk factors in patients with acute cerebral infarction

Objective To investigate the relationship between cerebral arterial stenosis and risk factors in patients with acute cerebral infarction.Methods 230 in-patients with acute cerebral infarction were screened for cerebral arterial stenosis by magnetic resonance angiography and then classified into stenosis group（N=125） and control group（N=105）.The risk factors,such as age,sex,diabetes mellitus history,hypertension history,smoking were investigated.The blood-samples from 230 in-patients were measured by complete automatic blood-biochemistry analyzer.Results There was no significant difference in age,sex,hypertension history,smoking between the stenosis group and the control group.The levels of serum cholesterol,triglyceride,low-density lipoprotein cholesterol,lipoprotein（a）,bilirubin,uric acid in the stenosis group had no significant difference with the control group（P0.05）.Diabetes mellitus history and the levels of serum glucose in the stenosis group had significant difference with the control group.And the levels of high-density lipoprotein cholesterol in the stenosis group had significant difference with the control group（P0.05）.The result of logistic regression analysis indicated that high-density lipoprotein cholesterol was an independent risk factor.Conclusion The levels of serum glucose and high-density lipoprotein cholesterol are strongly and closely related to the occurrence and development of cerebral arterial stenosis in patients with acute cerebral infarction.