ACEI治疗肾性高血压和对肾机能的保护作用 |
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摘 要: |
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关 键 词: | 高血压,肾性 血管紧张素转换酶抑制剂 肾机能 血尿素氮 血肌酐 内皮素1 一氧化氮 |
The protection of renal function in the ACEI treatment of renal hypertension] |
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Authors: | Q L Zhou J H Yang L P Chen |
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Institution: | Xiangya Hospital, Hunan Medical University, Changsha 410008. |
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Abstract: | OBJECTIVE: To explore the influence of angiotensin-converting enzyme inhibitors (ACEI) on plasma endothelin (ET-1), nitric oxide (NO) and renal function in renal-hypertension patients. METHODS: Sixty renal-hypertension patients (Group II) were treated with ACEI (lotensin) for 10 weeks then we measure their blood pressure (BP), plasma ET-1, NO and renal functions (BUN, Scr and proteinuria) before and after the treatment. Thirty healthy persons (Group I) acted as control. RESULTS: The level of plasma ET-1 was higher and plasma NO was lower in Group II than those in Group I. After the treatment of ACEI plasma ET-1 and proteinuria were decreased (P < 0.01), and NO increased in Group II significantly (P < 0.01), while BUN and Scr decreased in abnormal-renal function patients (Group II2) (P < 0.05, P < 0.01). CONCLUSION: The Study indicates that: ACEI is effective to renal hypertension; it decreases plasma ET-1 and increases NO in the renal hypertension patients; ACEI may play an important role in protection of renal functions and prolonging the chronic renal failure. |
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