Anterior pituitary, adrenal, and gonadal hormones during cocaine withdrawal |
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| Authors: | J H Mendelson S K Teoh U Lange N K Mello R Weiss A Skupny J Ellingboe |
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| Affiliation: | Alcohol and Drug Abuse Research Center, Harvard Medical School/McLean Hospital, Belmont, MA 02178. |
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| Abstract: | Plasma luteinizing hormone (LH), prolactin, testosterone, and cortisol levels were determined in 16 patients after hospital admission for cocaine abuse, during the course of 4 weeks of hospitalization, and before discharge. Hyperprolactinemia was found at admission (mean +/- SD, 27.5 +/- 10.2 ng/ml) and persisted until discharge (mean +/- SD, 28.7 +/- 10.8 ng/ml). Plasma LH, testosterone, and cortisol levels were within normal limits. These findings suggest that persistent elevation of plasma prolactin levels after cocaine withdrawal may reflect a chronic cocaine-induced derangement in neural dopaminergic regulatory systems. |
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