| 重组人铜锌超氧化物歧化酶脂质体的制备 |
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| 引用本文： | 谢帮铁,工晶翼,骆训懿,李战青,刘晓琳,陈晓穗,陈宇萍,周丽君,朱迎春. 重组人铜锌超氧化物歧化酶脂质体的制备[J]. 海军总医院学报, 1994, 0(3) |
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| 作者姓名： | 谢帮铁 工晶翼 骆训懿 李战青 刘晓琳 陈晓穗 陈宇萍 周丽君 朱迎春 |
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| 作者单位： | 海军总医院分子生物学研究室 |
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| 摘 要： | 应用反相蒸发法制备出重组人铜锌超氧化物歧化酶(rh Cu/Zn SOD)脂质体,其包封率为49.1%,在大鼠体内半衰期为3.45 h,体外模拟胃酸、胃蛋白酶、胰酶耐受力分别为90.3%、86.2%.79.8%;在小鼠体内脾、肝、肺脏中分布最高.
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| 关 键 词： | 超氧化物歧化酶 脂质体 基因工程 |
Preparation of Liposome-entraped Reconbinent Human Cu/Zn Superoxide Dismutase |
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| Xie Bangtie et al. Preparation of Liposome-entraped Reconbinent Human Cu/Zn Superoxide Dismutase[J]. Journal of Naval General Hospital of PLA, 1994, 0(3) |
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| Authors: | Xie Bangtie et al |
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| Affiliation: | Xie Bangtie et al |
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| Abstract: | Reconbinent human Cu/Zn superoxide disumtase (rh Cu/Zn SOD)liposome was per-pared by reverse-phase evaporation method. The encapsulation rate was 49.1%,the half-life of SOD inWistar rats was 3.45 h and simulated endruances against gastric acid, pepsin and pancreatin in vitro were 90.3% , 86.2%and 79.8% respectively. The resultes of this experiment showed that rh Cu/ZnSOD was highly distributed in some organs, especially, especially in spleen, lung and liver. |
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| Keywords: | Superoxide dismutase Liposome Genetic engineering |
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