| 乌苯美司对小鼠白细胞介素─2的影响 |
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| 引用本文： | 沈炜明,胡其乐,陈荣秀,翟晓波,陆瑶华.乌苯美司对小鼠白细胞介素─2的影响[J].中国新药与临床杂志,1995(4). |
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| 作者姓名： | 沈炜明 胡其乐 陈荣秀 翟晓波 陆瑶华 |
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| 作者单位： | 上海市第六人民医院临床药学研究室，华西医科大学基础免疫研究室，上海市中华制药厂药物研究所 |
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| 摘 要： | 目的：观察乌苯美司（ｕｂｅｎｉｍｅｘ，ＵｂＣ）对小鼠白细胞介素－２（ＩＬ－２）生成及反应性的影响。方法：Ｃ５７ＢＬ／６小鼠ｉｇ或ｉｐＵｂｅ５ｍｇ／（ｋｇ·ｄ）×７ｄ，在ｄ３给环磷酰胺（Ｃｙｃ）１次ｉｐ，１００ｍｇ／ｋｇ，ｄ８取小鼠脾细胞。用ＩＬ－２依赖性淋巴细胞株（ＣＴＬＬ）［３Ｈ］ＴｄＲ参入法，测定ＩＬ－２含量。结果：Ｕｂｅ能显著增加小鼠淋巴细胞的生成，增强对ＩＬ－２的反应性，但不影响血清中ＩＬ－２抑制物的活性。Ｃｙｃ对小鼠ＩＬ－２生成及ＩＬ－２反应性有较强的抑制作用，此作用在一定程度上可被Ｕｂｅ逆转。结论：Ｕｂｅ对小鼠ＩＬ－２生成及反应性有显著促进作用，且可拮抗Ｃｙｃ对ＩＬ－２生成的抑制。
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| 关 键 词： | 乌苯美司 白细胞介素－2 小鼠 抗肿瘤药 |
Effects of ubenimex on interleukin-2 in mice |
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| SHEN wei-Ming, HU Qi-Le,.Effects of ubenimex on interleukin-2 in mice[J].Chinese Journal of New Drugs and Clinical Remedies,1995(4). |
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| Authors: | SHEN wei-Ming HU Qi-Le |
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| Abstract: | AIM :To observe the effects of ubenimex (Ube) on interleukin-2 (IL-2) production and response in mice. METHODS: Ube 5 mg/(kg·d)ig or ip was given for 7 d in C57BL/6 mice. Cyclophosphamide(Cyc)100 mg/kg ip was given on d 3. Mouse splenocytes were determined for IL-2 content on d8 by￣3H]TdR incorporation of CTLL. RESULTS : Ube increased the abilities of the mouse splenocytes to produce IL-2 and to respond to IL-2,but did not alter the activity of IL-2 inhibitor in mouse sera. Cyc had strong inhibitory effects on IL-2 production and response of mouse lymphocytes. This action was reversed to a certain extent by Ube. CONCLUSION: Ube had enhanced IL-2 production and response in mice, and antagonized the inhibition to IL-2 production by Cyc. |
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| Keywords: | ubenimex interleukin-2 mice antineoplastic agents |
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