| 脊髓损伤对大鼠睾丸生精细胞iNOS、Bcl-2基因表达的影响 |
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| 引用本文： | 魏勇,张孝斌,张杰,程帆.脊髓损伤对大鼠睾丸生精细胞iNOS、Bcl-2基因表达的影响[J].中华男科学杂志,2003,9(1):28-31,54. |
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| 作者姓名： | 魏勇 张孝斌 张杰 程帆 |
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| 作者单位： | 武汉大学人民医院泌尿外科,湖北,武汉,430060 |
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| 摘 要： | 目的 :探讨大鼠脊髓损伤后生精细胞减少的影响因素。 方法 :6 0只SD大鼠随机分为脊髓损伤手术组(n =4 0 )和假手术组 (n =2 0 ) ,应用免疫组化S P法检测脊髓损伤大鼠术后第 2周、第 4周睾丸生精细胞iNOS、Bcl 2表达情况。 结果 :术后第 2周 ,手术组大鼠睾丸生精细胞中iNOS表达与假手术组比较显著增强 (P <0 .0 5 ) ,Bcl 2表达与假手术组比较差异无显著性。术后第 4周 ,手术组大鼠与假手术组比较 ,睾丸生精细胞中iN OS表达显著增强 (P <0 .0 5 ) ,Bcl 2表达显著性减少 (P <0 .0 5 )。 结论 :脊髓损伤后iNOS表达的增强与Bcl 2表达的减少是造成生精细胞显著减少的原因之一
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| 关 键 词： | 生精细胞 脊髓损伤 诱导型一氧化氮合酶 Bcl2 大鼠 |
| 文章编号： | 1009-3591(2003)01-0028-05 |
| 修稿时间： | 2002年4月27日 |
Effect of Spinal Cord Injury on iNOS and Bcl-2 Gene Expression in Spermatogenic Cell of the Male Rat |
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| Yong WEI,Xiao Bin ZHANG,Jie ZHANG,Fan CHENG.Effect of Spinal Cord Injury on iNOS and Bcl-2 Gene Expression in Spermatogenic Cell of the Male Rat[J].National Journal of Andrology,2003,9(1):28-31,54. |
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| Authors: | Yong WEI Xiao Bin ZHANG Jie ZHANG Fan CHENG |
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| Institution: | Department of Urology, the Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China. |
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| Abstract: | Objectives: To investigate the cause of spermatogenic cells decreasing after spinal cord injury. Methods: Immunohistochemical S P method was used to detect the expression of iNOS and Bcl 2 protein in the testis of spinal cord injuried and sham operated adult rats in second week and fourth week after operation. Results: Second week and fourth week after operation, the expression of iNOS of operated rats increased significantly ( P < 0.05 ).Fourth week after operation, the number of Bcl 2 positive cells in spinal cord injuried group decreased significantly ( P < 0.05 ). Conclusions: The expression veition of iNOS and Bcl 2 is the cause that inducing the decrease of spermatogenic cells in testis of spinal cord injuried rats. Natl J Androl,2003,9(1):28 31 |
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| Keywords: | Spinal cord injury Spermatogenic cell iNOS Bcl 2 Rat |
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