血清B2微球蛋白在评价高龄慢性肾脏病患者肾功能中的作用

目的探讨血清B2微球蛋白（B2-MG）在高龄慢性肾脏病（CKD）患者肾小球滤过率（GFR）的评估价值。方法选择高龄男性CKD病患者57例，SPECT检测患者肾小球滤过率，检测血清胆-MG、血肌酐（SCr）、血清半胱氨酸蛋白酶抑制剂C（CysC）水平。结果血清B2-MG水平不受年龄、体质量、身高等影响（P〉0．05），在CKD3～5期存在统计学差异（P〈0．05）。血清B2-MG与肾小球滤过率相关性系数在CKD5期最高，CKD3～5期性均低于SCr；在CKD3、4期稍优于CysC，在5期低于CysC。结论血清胆-MG在高龄CKD5期与肾小球滤过率相关性最高，在CKD3～5期也许不优于SCr，能否作为高龄CKD肾小球率过滤评价较好的指标还需要大样本研究进一步的证实。

Potential role of B2-microglobulin for glomeralar filtration rate of senile patients with chronic kidney dis-ease

Objective To evaluate the potential role of B2-Microglobulin （B2-MG） for glomeru- lar filtration rate （GFR） of senile patients with chronic kidney disease （CKI））. Methods Fifty-seven male CKD senile patients were selected for detecting GFR by SPECT, and concentrations of serum B2- MG,serum creatinine （SCr） and serum Cystatin C （Cys C） were determined. The results were ana- lyzed statistically. Results The concentration of serum B2-MG was not affected by year, weight and height （P：~0. 05）. The average concentration of serum B2-MG had significant difference among stages 3,4,and 5 of CKD patients,and the highest correlation coefficient to GFR was in patients with stage 5 CKD （P〈0. 05）. The correlation coefficients of serum B2-MG to GFR were lower than those of SCr in stages 3 to 5 CKD patients; and higher than those of serum Cys C in stage 3 to 4 CKD patients but lower in stage 5（P~0. 05）. Conclusions The highest correlation coefficient of serum B2-MG to GFR was in stage 5 senile CKD patients, and the correlation coefficient of B2-MG to GFR might be lower than that of SCr in stage 3-5 of senile CKD patients. Whether serum B2-MG was the reasonable maker evaluating G-FR of senile CKD patients needed advanced researching in future.