Diffusion tensor imaging of the normal prostate at 3 Tesla |
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Authors: | Bengi Gürses Neslihan Kabakci Arzu Kovanlikaya Zeynep Firat Ali Bayram Aziz Müfit Ulu? ?lhami Kovanlikaya |
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Institution: | (1) Department of Radiology, Yeditepe University Hospital, Kozyatagi, Istanbul, 34752, Turkey;(2) Department of Biomedical Engineering, Yeditepe University, School of Engineering, Kayisdagi, Istanbul, 34755, Turkey;(3) Department of Radiology, Weill Medical College of Cornell University, New York, NY 10021, USA;(4) Yeditepe üniversite Hastanesi, Devlet Yolu Ankara Caddesi, No: 102-104, Kozyatagi, 34752 İstanbul, Turkey |
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Abstract: | The aim of this study was to assess the feasibility of diffusion tensor imaging (DTI) of the prostate and to determine normative
fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of healthy prostate with a 3-Tesla magnetic resonance
imaging (MRI) system. Thirty volunteers with a mean age of 28 (25–35) years were scanned with a 3-Tesla MRI (Intera Achieva;
Philips, The Netherlands) system using a six-channel phased array coil. Initially, T2-weighted turbo spin-echo (TSE) axial
images of the prostate were obtained. In two subjects, a millimetric hypointense signal change was detected in the peripheral
zones on T2-weighted TSE images. These two subjects were excluded from the study. DTI with single-shot echo-planar imaging
(ssEPI) was performed in the remaining 28 subjects. ADC and FA values were measured using the manufacturer supplied software
by positioning 9-pixel ROIs on each zone. Differences between parameters of the central and peripheral zones were assessed.
Mean ADC value of the central (1.220 ± 0.271 × 10−3 mm2/s) was found to be significantly lower when compared with the peripheral gland (1.610 ± 0.347 × 10−3 mm2/s) (P < 0.01). Mean FA of the central gland was significantly higher (0.26), compared with the peripheral gland (0.16) (P < 0.01). This study shows the feasibility of prostate DTI with a 3-Tesla MR system and the normative FA and ADC values of
peripheral and central zones of the normal prostate. The results are compatible with the microstructural organization of the
gland.
An erratum to this article can be found at |
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Keywords: | Prostate MRI Diffusion |
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