清肝祛湿活血方治疗非酒精性脂肪肝的疗效评价

目的:观察清肝祛湿活血方治疗非酒精性脂肪肝患者的临床疗效,并探讨其作用机制。方法:将112例非酒精性脂肪肝患者采用随机数字表法分为对照组(57例)和治疗组(55例)。对照组给予多烯磷脂酰胆碱胶囊;治疗组给予清肝祛湿活血方。治疗2个月,观察治疗前后两组患者消化系统彩超、肝功能、血脂水平、胰岛素抵抗指数(HOMA-IR)、体重指数(BMI)、腰围和证候积分。结果:治疗组总有效率优于对照组(P0.05);与治疗前比较,治疗后两组患者的谷丙转氨酶(ALT),谷草转氨酶(AST),总胆固醇(TC),甘油三酯(TG),低密度脂蛋白胆固醇(LDL-C),HOMA-IR,BMI及腰围均明显下降(P0.05,P0.01),且治疗组优于对照组(P0.05)。结论:清肝祛湿活血方能够显著改善非酒精性脂肪肝患者临床症状,降低体重指数、腰围,改善肝功能、胰岛素抵抗,调节血脂代谢。

Efficacy of Qinggan Qushi Huoxue Decoction in Treatment of Nonalcoholic Fatty Liver

Objective: To evaluate the clinical efficacy of Qinggan Qushi Huoxue decoction in treatment of patients with nonalcoholic fatty liver. Method: Totally 112 cases of nonalcoholic fatty liver patients were randomly divided into control group (57 cases) and treatment group (55 cases). Control group was given polyene phosphatidylcholine capsules, treatment group was treated with Qinggan Qushi Huoxue decoction. The treatment lasted for two months. Before and after the treatment, patients'' digestive system ultrasound, liver function, blood lipid, insulin resistance index (HOMA-IR), weight index (BMI), waist circumference and symptom scores were observed. Result: The treatment group showed a total effective rate of 100%, which was higher than control group (P<0.05), compared with before treatment, two groups of patients showed significant decreases in alanine aminotrans-ferase (ALT), aspirate aminotrans-ferase (AST), total cholesterol (TC), triglyeride (TG), low density lipoprotein cholesterol (LDL-C), HOMA-IR, BMI and waist circumference after treatment (P<0.05,P<0.01), and treatment group was better than control group (P<0.05). Conclusion: Qinggan Qushi Huoxue decoction can significantly alleviate the clinical symptoms of patients with alcoholic fatty liver, reduce their weight index and waistline, alliviate liver function and insulin resistance, and regulate lipid metabolism.