血栓前状态与高血压病的关系

目的判断原发性高血压是否存在血栓前状态,并探讨血栓前状态在原发性高血压中的意义。方法运用酶联免疫吸附双抗体夹心法(ELLSA)、酶联免疫吸附竞争法、发色底物法、凝固法等手段,检测了1 000例原发性高血压病患者和100例健康成人的6-酮-前列腺素Fla(6-K-PGFla)含量、血栓素B2(TXB2)、纤维蛋白原(Fbg)、组织型纤溶酶原激活剂(t-PA)及纤溶酶原激活抑制物-1(PAI-1)的含量和活性、血液流变学等指标的变化并进行分析与评价。结果1-2级高血压组及3级高血压组病人,血浆TXB2、PAI-1含量及活性、血黏度、Fbg水平均明显高于对照组(P< 0.01);而t-PA含量及活性、6-K-PGFl a含量均显著下降(P<0.01)。结论高血压病患者存在血栓前状态。血栓前状态与高血压患者的病情发展,血栓栓塞性疾病的发生密切相关。

Study on Prethrombotic State in Patients with Hypertension

Objective To study prethrom botic state and its sigmificance in hypertensive patients. Methods A series of molecular markers,that is ,thromboxane B2 (TXB2) ,6-keto-prostagland in Fla (6-KPGFla) .tissue-type plasminogenactivator (t-PA) and its in hibitor (PAI-1 ) were measured in 1 000 patients with 1st,2nd and 3rd degree of essential hypertension and 100 normotensive controls by therad immunoassay, the chromogenic subst rate and theenzyme linked immunosorbent assay ( ELISA) respectively. The indexes of hemorheology were a Isostudied in the subjects. Results As compared with controls, plasma levels of TXB2,tPAI-1 antigen,PAI-1 antigen and activity, blood viscosity and plasma fibrinogen were found significantly higher (P < 0. 05) in hypertensive patients; but t-PA activity, and 6-k-PGF1 a were lower (P < 0. 05). Conclusion Prethrombotic state is present in hypertensive patients and may be increased blood pressure. This explains in part why the thrombotic complications are common in hypertensive patients.