首页 | 本学科首页   官方微博 | 高级检索  
     

血栓前状态与高血压病的关系
引用本文:宗俊学,芦璐,徐洪玉. 血栓前状态与高血压病的关系[J]. 血栓与止血学, 2005, 11(1): 21-23
作者姓名:宗俊学  芦璐  徐洪玉
作者单位:山东省血栓病防治工程技术研究中心,山东省交通医院,济南,250031
摘    要:目的判断原发性高血压是否存在血栓前状态,并探讨血栓前状态在原发性高血压中的意义。方法运用酶联免疫吸附双抗体夹心法(ELLSA)、酶联免疫吸附竞争法、发色底物法、凝固法等手段,检测了1 000例原发性高血压病患者和100例健康成人的6-酮-前列腺素Fla(6-K-PGFla)含量、血栓素B2(TXB2)、纤维蛋白原(Fbg)、组织型纤溶酶原激活剂(t-PA)及纤溶酶原激活抑制物-1(PAI-1)的含量和活性、血液流变学等指标的变化并进行分析与评价。结果1-2级高血压组及3级高血压组病人,血浆TXB2、PAI-1含量及活性、血黏度、Fbg水平均明显高于对照组(P< 0.01);而t-PA含量及活性、6-K-PGFl a含量均显著下降(P<0.01)。结论高血压病患者存在血栓前状态。血栓前状态与高血压患者的病情发展,血栓栓塞性疾病的发生密切相关。

关 键 词:高血压 血栓前状态 分子标志物
文章编号:1009-6213(2005)01-021-03
修稿时间:2004-12-20

Study on Prethrombotic State in Patients with Hypertension
ZONG Jun-xue,LU Lu,Hong-yu. Study on Prethrombotic State in Patients with Hypertension[J]. Chinese Journal of Thrombosis and Hemostasis, 2005, 11(1): 21-23
Authors:ZONG Jun-xue  LU Lu  Hong-yu
Abstract:Objective To study prethrom botic state and its sigmificance in hypertensive patients. Methods A series of molecular markers,that is ,thromboxane B2 (TXB2) ,6-keto-prostagland in Fla (6-KPGFla) .tissue-type plasminogenactivator (t-PA) and its in hibitor (PAI-1 ) were measured in 1 000 patients with 1st,2nd and 3rd degree of essential hypertension and 100 normotensive controls by therad immunoassay, the chromogenic subst rate and theenzyme linked immunosorbent assay ( ELISA) respectively. The indexes of hemorheology were a Isostudied in the subjects. Results As compared with controls, plasma levels of TXB2,tPAI-1 antigen,PAI-1 antigen and activity, blood viscosity and plasma fibrinogen were found significantly higher (P < 0. 05) in hypertensive patients; but t-PA activity, and 6-k-PGF1 a were lower (P < 0. 05). Conclusion Prethrombotic state is present in hypertensive patients and may be increased blood pressure. This explains in part why the thrombotic complications are common in hypertensive patients.
Keywords:Hypertension  Prethrombotic state  Molecular marker
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号