早期镇痛疗法治疗复发性口腔溃疡的临床研究

目的:探讨早期镇痛疗法对复发性口腔溃疡(RAU)的疗效及临床意义.方法:选择复发性口腔溃疡患者60例,随机分为两组,每组30例.治疗组口服万络,50mg/天;对照组口服替硝唑1.0g/天,观察镇痛疗法对溃疡愈合的影响.结果:治疗、对照组用药2天的痊愈率:治疗组为13.33%,对照组为0%,有显著性差异(P＜0.05);治疗、对照组2天总有效率分别为80%和10%,有显著性差异(P＜0.05);治疗4天的痊愈率,镇痛治疗组为73.33%,明显高于对照组33.33%,有显著性差异(P＜0.05);治疗、对照组4天总有效率分别为93.33%和80%,差异不显著(P＞0.05).结论:早期镇痛疗法治疗RAU具有缓解持续顽固性疼痛、快速治愈口腔溃疡、改善进食状况的作用.

CLINICAL STUDY ON THE EFFECTS OF PREEMPTIVE ANALGESIA ON RECURRENT APHTHOUS ULCERS

Objective: To study the therapeutic effects of preemptive analgesia on recurrent aphthous ulcers(RAU). Methods: 60 patients with RAU were randomly divided into the treatment group (Rofecoxib 50mg/d) and control group (Tinidazole 1,000mg/d). Results: The healing rate of the treatment group (13.33%) after 2 days was significantly higher than that of the control group (0%) ( P <0.05). There were also obvious differences of the effective rate after 2 days between the treatment group (80%) and control group (10%) ( P <0.05). There was no significant differences of total effective rate after 4 days between the treatment group(93.33%) and control group (80%) ( P >0.05), although the healing rate of treatment group (73.33%) was significantly higher than that of the control group (33.33%)( P <0.05). Conclusion: The preemptive analgesia is a good method in treatment of RAU. It could be useful for relieving intractable pain and improving food taking of patients.