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术中淋巴结示踪定位技术对进展期胃癌淋巴清扫指导作用的研究
引用本文:刘江文,仝德峰,牛建华,夏军强,王奇,邓昌辉,胡建昆.术中淋巴结示踪定位技术对进展期胃癌淋巴清扫指导作用的研究[J].实用肿瘤杂志,2011,26(4):369-371.
作者姓名:刘江文  仝德峰  牛建华  夏军强  王奇  邓昌辉  胡建昆
作者单位:1. 石河子大学医学院第三附属医院普外一科,新疆,石河子,832000
2. 石河子大学医学院第一附属医院普外三科,新疆,石河子,832000
3. 四川大学华西医院胃肠外科,四川,成都,610041
基金项目:兵团重点科技攻关计划项目(2008GG37)
摘    要:目的探讨术中淋巴结示踪定位技术对进展期胃癌淋巴清扫的指导作用。方法术中肿瘤周围注射第三代淋巴结示踪剂——纳米炭混悬液,在D2根治术的基础上以黑染淋巴结为导向进行个体化清扫。统计清扫淋巴结的数目及淋巴结转移情况、黑染情况,并观察不良反应及并发症的发生。结果本组平均每例清扫淋巴结(35.1±13.4)枚,其中阳性淋巴结(6.9±2.5)枚;淋巴结黑染率为52.7%,黑染淋巴结中发生转移的阳性率(27.6%),高于未黑染淋巴结(10.8%),差异有统计学意义(χ2=6.034,P=0.016);本组发生1例输入襻梗阻。结论进展期胃癌在D2根治术的基础上以术中淋巴显影技术为指导进行个体化清扫,能增加淋巴结清扫的彻底程度,并可提高清扫转移淋巴结的效率,但肿瘤进展程度会影响淋巴显影效果。

关 键 词:胃肿瘤/外科学  胃肿瘤/病理学  淋巴结/代谢  纳米技术  染色与标记  炭/药代动力学  淋巴结切除术

Lymph node dissection guided by intraoperative lymphatic mapping in advanced gastric cancer
LIU Jiang-wen,TONG De-feng,NIU Jian-hua,et al.Lymph node dissection guided by intraoperative lymphatic mapping in advanced gastric cancer[J].Journal of Practical Oncology,2011,26(4):369-371.
Authors:LIU Jiang-wen  TONG De-feng  NIU Jian-hua  
Institution:LIU Jiang-wen1,TONG De-feng1,NIU Jian-hua2,et al (1.Department of General Surgery,The Third Affiliated Hospital,College of Medicine,Shihezi University,Shihezi,832000,China,2.Department of General Surgery,The First Affiliated Hospital,China)
Abstract:Objective To evaluate lymph node dissection guided by intraoperative lymphatic mapping in patients with advanced gastric cancer. Methods During the operation carbon nanoparticles suspension was injected around the tumor,on the basis of D2 lymphadenectomy the dissection was guided by the black-stained lymph nodes.The number of removed lymph nodes,the condition of lymphatic metastasis and black-stained lymph nodes,the side effects and postoperative complications were analyzed,respectively. Results The number ...
Keywords:stomach neoplasms/surgery  stomach neoplasms/pathology  lymph nodes/metabolism  nanotechnology  staining and labeting  charcoal/pharmacokinetics  lymph node excision  
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