子宫内膜癌组织中成纤维细胞激活蛋白的表达及其与微血管密度的关系

目的 探讨成纤维细胞激活蛋白(FAP)在子宫内膜癌间质中的表达及其与微血管密度(MVD)的关系.方法 收集82例子宫内膜癌组织及20例经病理证实的子宫内膜息肉,采用免疫组织化学染色法检测FAP和微血管特异性标记物CD34的表达.分析FAP表达与MVD的关系.结果 在子宫内膜癌组织中,FAP表达于间质成纤维细胞,表达阳性率为89.02%(73例),而子宫内膜癌细胞和子宫内膜息肉中无表达.FAP表达和MVD分别与子宫内膜癌的分化程度、侵袭深度及淋巴结转移有关(均P＜0.01).随着FAP表达水平的增高,MVD也随之增加.结论 FAP的表达与子宫内膜癌的分化程度、侵袭深度及淋巴结转移有关.FAP可能通过促进肿瘤的微血管生成,加快肿瘤的生长、侵袭和转移.

The relation between fibroblast activation protein expression and microvessel density in the stroma of endometrial carcinoma

Objective To investigate the expression of fibroblast activation protein(FAP) in endometrial carcinoma and the relationship between FAP expression and microvessel density(MVD). Methods Endometrial carcinoma tissue from 82 patients and endometrial polyp tissue from 20 patients confirmed by pathological examination were available for study. The expression of FAP and CD34 in endometrial carcinoma tissue and endometrial polyp tissue were detected by immunohistochemistry. Results The positive rate of FAP expression in stromal fibroblasts was 89.02% (73 cases)in patients with endometrial carcinoma tissue, while carcinoma cells and endometrial polyp tissues were negative for FAP. In endometrial carcinoma, FAP expression and MVD were associated with tumor differentiation, invasion and lymph node metastasis(P ＜0.01), respectively. MVD was significantly correlated with FAP intensity in endometrial carcinoma. Conclusions In endometrial carcinoma tissue, FAP expression correlates with the invasion and metastasis. FAP may promote tumor growth, invasion and metastasis by facilitating tumor angiogenesis.