| 北豆根总碱注射液抗实验性心律失常作用 |
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| 引用本文： | 刘秀华,韩福林. 北豆根总碱注射液抗实验性心律失常作用[J]. 黑龙江医药, 2000, 13(3): 160-162 |
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| 作者姓名： | 刘秀华 韩福林 |
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| 作者单位： | 黑龙江省医药工业研究所药理室,150040 |
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| 摘 要： | 采用五种实验动物心律失常模型观察了北豆根总碱（Ｔｏｔａｌ Ａｌｋａｌｏｉｄ ｏｆ Ｍｅｎｉｓｐｅｒｍｕｍ Ｄａｕｒｉｃｕｍ，简称ＴＡＭＤ）注射液的抗心失常作用。结果表明ｉｖ ５ｍｇ／ｋｇ＾－１ＴＡＭＤ对氯化钡诱发大鼠心失常的治疗作用明显优于１０ｍｇ／ｋｇ＾－１奎尼丁，对乌头碱诱发心失常预防作用优于利多卡因，对抗喹因诱发豚鼠的心律失常与利多卡因相似，对氯仿诱发小鼠室颤有保护作用且优于硅尼丁；对大鼠冠
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| 关 键 词： | 北豆根总碱注射液 大鼠 心律失常 |
| 修稿时间： | 1999-12-23 |
Effects of Total Alkaloid of Menispermum Dauricum on Experimental Models of Dysrhythm |
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| Liu Xiuhua,Han Fulin. Effects of Total Alkaloid of Menispermum Dauricum on Experimental Models of Dysrhythm[J]. Heilongjiang Medicine, 2000, 13(3): 160-162 |
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| Authors: | Liu Xiuhua Han Fulin |
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| Affiliation: | Liu Xiuhua;Han Fulin Heilongjiang Pharmaceutical Industry Instate 150040 |
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| Abstract: | The effects of Total Alkaloid of Menispermum Dauricum(TAMD)on five experimental models of dysrhythm were studied.The result indicated that therapeutic action of TAMD was obviously better than Quinidine on dysrhythm of Rat induced by BaCl_2;Preventive effect of TAMD on dysrhythm of Rat caused by Aconitine was stronger than Lidocaine;Effect of TAMD was Similar to Lidocaine on dysrhythm of Guinea pig produced by Ouabain;Protective action of TAMD was much greater than Quinidine on ventricular fibrillation triggered by Chloroform in Mice;Protective effect of TAMD was similar to Lidocaine on dysrhythm caused by coronary occlusion and reperfusion in Rat. |
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| Keywords: | TAMD Quinidine Lidocaine Acontine Ouabain Dysrhythm |
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