Dopamine transporter imaging with novel, selective cocaine analogs. |
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| Authors: | U Scheffel R F Dannals D F Wong F Yokoi F I Carroll M J Kuhar |
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| Affiliation: | Division of Nuclear Medicine and Radiation Health Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21205. |
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| Abstract: | RTI-121 and RTI-122 are 3 beta-substituted phenyltropane analogs of cocaine that have high, selective binding affinity for dopamine transporters. [123I]RTI-121 and [123I]RTI-122 bind to dopamine transporters in vivo after intravenous administration and permit imaging of the transporters. |
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