Cerebral hypoxia-ischemia in immature rats: methodological considerations |
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Authors: | B E Dwyer R N Nishimura D G Fujikawa |
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Affiliation: | Epilepsy Research Laboratory, Veterans Administration Medical Center, Sepulveda, California 91343. |
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Abstract: | We used a model of perinatal hypoxic/ischemic brain damage which combines unilateral common carotid artery ligation and hypoxia (8% O2). Protein synthesis inhibition and cell loss were found in the ipsilateral forebrain of 11-day-old rats when hypoxia was initiated 4 h but not 24 h after carotid ligation. [14C]Iodoantipyrine uptake studies suggest that compensating vascular changes which protect the ipsilateral forebrain occur within 24 h of carotid ligation. |
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