血尿酸水平与大面积脑梗死的相关性

目的探讨血尿酸（BUA）水平与大面积脑梗死的相关性。方法选择新发大面积脑梗死患者95例（观察组）和同期健康体检者95例（对照组），检测两组BUA、空腹血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL—C）及梗死面积，分析BUA水平与脑梗死面积的相关性。结果观察组BUA、FPG、TG、TC、LDL-C均高于对照组（P均〈0．01）。多因素Logistic回归分析显示，BUA水平升高是脑梗死的危险因素（OR=1．005，95％CI=1．002～1．008，P=0．001）。脑梗死灶越大，患者BUA水平越高（P〈0．05）。结论高尿酸血症是大面积脑梗死的独立危险因素，且脑梗死的面积与BUA水平呈正相关。

Correlation between blood uric acid level and massive cerebral infarction

Objective To investigate the relationship between the blood uric acid （BUA） level and massive cerebral infarction. Methods Blood uric acid （BUA）, fasting plasma glucose （FPG）, triglycerides （TG）, total cholesterol （ TC）, low-density lipoprotein cholesterol （LDL-C） and the infarction size were detected in 95 new cases of patients with massive cerebral infarction （ observation group） and 95 healthy controls （ control group）, and then the relationship between the BUA level and massive cerebral infarction was analyzed. Results The levels of BUA, FPG, TG, TC, and LDL-C were significantly higher in the observation group than those of the control group （ all P 〈 0.01 ）. Multivariate Logistic re- gression analysis showed that the increased BUA level was the risk factor for the cerebral infaetion （ OR = 1. 005, 95% CI = 1. 002 - 1. 008, P =0. 001 ）, and the larger the infarction size is, the higher the BUA level （P 〈0.05 ）. Conclusions Hyperuricemia is an independent risk factor for massive cerebral infarction, and cerebral infarction area is positively cor- related with BUA level.