头穴丛刺对慢性酒精中毒大鼠学习记忆能力及TH表达的干预作用

目的：探讨头穴丛刺对慢性酒精中毒大鼠的学习记忆能力及酪氨酸羟化酶（TH）表达的影响。方法：通过酒精灌胃的方法,建立慢性酒精性中毒大鼠的模型,运用Morris圆形水迷宫、免疫组化等方法及手段,观察头穴丛刺对慢性酒精中毒性大鼠学习记忆能力和TH表达的影响。结果：头穴组大鼠水迷宫逃避潜伏期较模型组明显缩短（P〈0.05）;免疫组化检测头穴组酪氨酸羟化酶的表达明显高于模型组（P〈0.05）。结论：头穴丛刺可能通过促进TH表达,从而改善慢性酒精中毒大鼠的学习记忆能力。

Interventive Effects of Cluster Scalp Acupuncture on Learning and Memory in Chronic Alcoholism and TH Expression in Rats

Objective： To study the effect of scalp cluster acupuncture on learning and memory ability in rats with chronic alcoholism and tyrosine hydroxylase（ TH） expressions of rats. Methods： After intragastric infusion with alcohol,establish rat models of chronic alcoholic poisoning,using round Morris water maze,immunohistochemical methods and means,observe the effect of scalp cluster acupuncture on learning and memory ability and expression of TH in rats with chronic alcohol intoxication. Results： The group of scalp acupuncture on rats with water maze escape latency was significantly shortend compared with the model group（ P〈0. 05）; according to the immunohistochemical detection,in the group with scalp acupuncture the tyrosine hydroxylase expression was significantly higher than that in the model group（ P〈0. 05）. Conclusion： Scalp cluster-needling may be expressed through promotion of TH,thereby improving the ability of learning and memory of chronic alcoholism in rats.