Fluoride release from CaF2 and enamel demineralization |
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Authors: | Tenuta L M A Cerezetti R V Del Bel Cury A A Tabchoury C P M Cury J A |
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Institution: | Piracicaba Dental School, UNICAMP, Av. Limeira 901, 13414-903, Piracicaba, SP Piracicaba, SP, Brazil. litenuta@fop.unicamp.br |
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Abstract: | The anticaries effect of professional fluoride (F) application has been attributed to calcium-fluoride-like deposits (CaF(2)) formed on enamel, but this has not been clearly demonstrated. We hypothesized that CaF(2) formed on plaque-free enamel by F application would reduce enamel demineralization due to the increase of F availability in fluid of subsequently formed plaque. We created distinct levels of CaF(2) on enamel to evaluate a dose-response effect. Enamel blocks were mounted in contact with a S. mutans test plaque and used in situ by 10 volunteers. F released to the fluid phase of this substrate ("plaque fluid") was measured before a cariogenic challenge. "Plaque fluid" F concentration was highly correlated to the enamel CaF(2) concentration (r = 0.96, p < 0.001) and to consequent enamel demineralization (r = -0.75, p < 0.001). The results suggest that F released to plaque fluid from CaF(2) formed on enamel may play a significant role in the anticaries effect of professionally applied F agents. |
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