五项诊断指标联合检测对糖尿病肾病的应用价值评价

目的探讨糖尿病肾病患者HCY、Cys-C、α1-MG、sTM及CRP等五项诊断指标的变化及其诊断价值。方法将292例糖尿病患者分为单纯性糖尿病组95例,早期糖尿病肾病组98例,临床糖尿病肾病组99例,与健康对照组102例平行检测上述五项指标。结果 DM组各项指标水平明显高于健康对照组,有显著统计学差异(P<0.01)。糖尿病肾病组血清五项指标水平组间存在显著差异(P<0.01)。并且随着DN病情进展,各项指标随着24h尿蛋白排泄率的增加逐渐增高(P<0.01),且互相之间关系密切,表明其升高与DN的发生、发展密切相关。在DM患者的病情发展过程中,HCY、Cys-C、α1-MG、sTM、CRP最早出现,可为疾病的早期诊断提供数据。结论血清HCY、CYS-C、α1-MG水平可作为DN早期肾损伤的反应肾小球滤过功能的敏感指标;sTM反映高HCY水平的DN患者的微血管损伤程度;CRP与DN患者病情正相关,可作为DN患者病情检测新指标,五者联合检测可提高检出敏感性及阳性率,全面协助DN肾损伤的早期诊断。

Application Value of Joint Detection of Five Diagnostic Indicators in the Diagnosis of Diabetics Nephropathy

Objective To study the change and the diagnostic value of Serum HCY、CYS-C、α1-MG、sTM and CRP in the diagnosis of diabetics nephropathy.Methods The 292 patients with diabeteswere divided into simple diabetic group 95 cases,early diabetic nephropathy 98 patients,clinical diabetic nephropathy 99 cases,with the healthy control group 102 cases,parallel detection of the five indicators.Results DM group was significantly higher than the target level of the control group,there was significant difference(P<0.01),the group of Diabetic nephropathy has significant differences between groups between The level of five indicators in the serum(P<0.01),and with the progress of the DN patient's condition,the diagnostic index gradually increased with the increase of UAER(P<0.01),and each of between closely related,indicating that increased with the DN of the occurrence and development is closely related to.The HCY、Cys-C、α1-MG、sTM、CRP earliest appear in the course of progression of DM,and can provide data for the early diagnosis of disease.Conclusion Serum HCY,CYS-C,α1-MG levels in patients with early renal damage as a glomerular filtration rate in response to a sensitive indicator;sTM reflects the high HCY levels in patients with microvascular injury;CRP positively correlated with the DN patient's condition,patient's condition can be detected as new indicators,Combined detection of five who can improve the detection sensitivity and positive rate,full assistance to the early diagnosis of renal injury in DN.