| 内毒素所致急性肺损伤发病机制的研究进展 |
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| 引用本文： | 李超然,王智刚,朱运奎. 内毒素所致急性肺损伤发病机制的研究进展[J]. 中国医药科学, 2011, 0(10): 47-49 |
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| 作者姓名： | 李超然 王智刚 朱运奎 |
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| 作者单位： | 兰州大学第二医院;兰州军区兰州总医院呼吸内科;兰州军区兰州总医院心血管内科 |
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| 基金项目： | 全军医药卫生科研基金资助项目(编号:06G029) |
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| 摘 要： | 急性肺损伤是临床常见的危重症。内毒素是导致急性肺损伤最常见的原因。近年来关于内毒素所致的急性肺损伤发病机制的研究发现:核转录因子κB、IL-8和中性粒细胞在促炎/抗炎反应的失衡中发挥重要作用,组织因子和肺泡上皮细胞在调节促凝/抗凝反应的失衡中发挥重要作用,而氧化应激和炎症反应之间可以相互促进。而且肺泡上皮细胞和PMN凋亡功能的紊乱、肺泡上皮细胞上Na+通道的下调、PMN释放的中性粒细胞弹性蛋白酶等在LPS导致的ALI发展过程中都发挥重要作用。
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| 关 键 词： | 急性肺损伤 内毒素 发病机制 |
Progress in Mechanisms Research of Lipopolysaccharide-induced Acute Lung Injury |
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| LI Chaoran,WANG Zhigang,ZHU Yunkui. Progress in Mechanisms Research of Lipopolysaccharide-induced Acute Lung Injury[J]. China Medicine and Pharmacy, 2011, 0(10): 47-49 |
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| Authors: | LI Chaoran WANG Zhigang ZHU Yunkui |
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| Affiliation: | 1.The Second Hospital Lanzhou University Lanzhou 730000 China;2.Department of Respiration Internal,Lan zhou General Hospital Military District Lanzhou 730000 China;3.Department of Heart and Blood Vessel Internal,Lanzhou General Hospital of Lanzhou Military District,Lanzhou 730000,China |
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| Abstract: | Acute Lung Injury is the common critical disease in hospital.And the lipopolysaccharide is the most common reason to induce ALI.Recent years,about the mechanisms of LPS-induced ALI researchers found tha:tNF-κB,IL-8 and PMN play an important role in the inflammatory reaction;Tissue factor and alveolar epithelial cells are important in regulating the coagulation;Oxidant stress and inflammatory reaction can facilitate each other.And also,the unnormal apoptosis of AEC and PMN,the down regulation of Na0+ channel in AEC and NE secreted by PMN are all important in the development of LPS-induced ALI. |
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| Keywords: | Acute Lung Injury LPS Mechanisms |
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