| 低分子肝素钠对原发性肾病综合征患者血清IL-8的影响 |
| |
| 引用本文： | 王洁,卢冬,林栩. 低分子肝素钠对原发性肾病综合征患者血清IL-8的影响[J]. 右江民族医学院学报, 2008, 30(6) |
| |
| 作者姓名： | 王洁 卢冬 林栩 |
| |
| 作者单位： | 右江民族医学院附属医院,广西,百色,533000 |
| |
| 摘 要： | 目的观察低分子肝素钠对原发性肾病综合征(PNS)患者血浆白介素-8(IL-8)的影响。方法PNS患者56例,其中低分子肝素钠治疗组(肝素组)30例,基础治疗组(基础组)26例,两组治疗前及治疗后第7天、第14天采用酶联免疫法测定血浆IL-8水平。设38例健康对照组作比较。结果PNS患者血浆IL-8水平明显高于健康对照组(P<0.01);肝素组治疗7天后血浆IL-8开始下降,但与治疗前比较差异无显著性(P>0.05),治疗14天后下降明显(P<0.01);基础组治疗前后血浆IL-8差异无显著性(P>0.05)。结论细胞因子异常参与PNS的发病过程,予低分子肝素钠治疗可以影响患者血浆中IL-8的水平,减轻PNS的肾损伤。
|
| 关 键 词： | 低分子肝素钠 肾病综合征 白细胞介素-8 |
Effects of low molecular weight heparin on serum interleukin-8 in primary nephrotic syndrome |
| |
| WANG Jie,LU Dong,LIN Xu. Effects of low molecular weight heparin on serum interleukin-8 in primary nephrotic syndrome[J]. Journal of Youjiang Medical College For Nationalities, 2008, 30(6) |
| |
| Authors: | WANG Jie LU Dong LIN Xu |
| |
| Affiliation: | WANG Jie,LU Dong,LIN Xu (Affiliated Hospital of Youjiang Medical College for Nationalities,Baise,Guangxi 533000,China) |
| |
| Abstract: | Objective To evaluate the effects of low molecular weight heparin(LMWH) on serum interleukin-8(IL-8) in patients with primary nephrotic syndrome(PNS).Methods Of 56 patients with PNS,30 cases received conventional therapy plus LMWH(heparin group),26 cases received conventional therapy alone(conventional group).An ELISA technique was used to measure the plasma levels of IL-8 before and on days 7 and 14 after drug administration.38 healthy individuals were chosen as control group.Results Plasma levels of IL-8 ... |
| |
| Keywords: | low molecular weight heparin primary nephritic syndrome interleukin-8 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
