1023中药合剂对实验性癌前损害癌变的阻断作用及其机制

目的:探讨1023中药合剂对口腔癌前损害癌变的阻断作用和作用机制.方法:用1023中药合剂(由黄芪、绞股蓝、川芎、富硒绿茶组成),对仓鼠颊囊实验性口腔癌前损害进行为期6周的治疗,观察其对癌变过程的阻断作用,并对1023中药合剂用药组的活检组织进行2种凝集素(麦胚凝集素和蓖麻凝集素)受体的测定.结果:1023中药合剂用药组的仓鼠癌变率明显低于不用任何药物的对照组(P＜0.05).1023中药合剂用药组的2种凝集素受体表达与对照组有明显差异.结论:1023中药合剂有阻止不典型增生癌变的作用,而且有一定的治疗作用;其作用机制可能是逆转癌前损害或诱导其向正常分化,并恢复其接触抑制功能.

Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism

Objective:To study the effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental oral precancerous lesion and its mechanism.Methods:We treated the experimental oral precancerous lesion in hamster's cheek pouch using 1023 Recipe (consisting of Radix Astragali, Gynostemma Pentaphyllum, Rhizoma Chuanxiong and selenium-rich green tea) for 6 weeks, and observed its effect in blocking cancer transformation, detected 2 kinds of agglutinin receptors (receptors of wheat germ agglutinin and Ricinus communis agglutinin) in the mucosa of the hamster's cheek pouch. Results:The rate of cancer transformation in 1023 Recipe treated group was lower than that in the control group without treatment (P<0.05). Agglutinin receptors in the two groups were different significantly.Conclusion:1023 Recipe is effective in treating hyperplasia,and can prevent its cancer transformation. The mechanism may be that 1023 Recipe can induce precancerous lesions to differentiate into normal tissues.