Cough augmentation in amyotrophic lateral sclerosis |
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| Authors: | Mustfa N Aiello M Lyall R A Nikoletou D Olivieri D Leigh P N Davidson A C Polkey M I Moxham J |
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| Affiliation: | Respiratory Muscle Laboratory, Guy's, King's and St. Thomas' School of Medicine, King's College Hospital, London, UK. naveed@doctors.org.uk |
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| Abstract: | Cough flows and pressures were measured during cough augmentation in healthy subjects and patients with bulbar and nonbulbar amyotrophic lateral sclerosis. Manual assistance increased flow 11% in bulbar (p < 0.01) and 13% in nonbulbar (p < 0.001) patients. Mechanical insufflation-exsufflation increased flow 17% in healthy subjects (p < 0.05), 26% (p < 0.001) in bulbar, and 28% (p < 0.001) in nonbulbar patients. The greatest improvements were in patients with the weakest coughs. Patient group and level of weakness influenced the effect of augmentation. |
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