Inflammatory pseudotumor of the pancreas |
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Authors: | Steven H. Kroft Steven J. Stryker Jane N. Winter Gulchi Ergun M. Sambasiva Rao |
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Affiliation: | (1) Department of Pathology, Northwestern University Medical School, Passavant Pavilion Rm. 316, 303 E. Superior, 60611 Chicago, IL;(2) Department of Surgery, Northwestern University Medical School, Passavant Pavilion Rm. 316, 303 E. Superior, 60611 Chicago, IL;(3) Department of Medicine, Northwestern University Medical School, Passavant Pavilion Rm. 316, 303 E. Superior, 60611 Chicago, IL |
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Abstract: | Summary We describe a rare example of inflammatory pseudotumor of the pancreas in a 42-yr-old woman, which developed following chemotherapy for lymphoma of the uterine cervix. The patient had developed fatigue, weight loss abdominal pain, and anemia; abdominal CT scan showed a large mass in the pancreas. Examination of the resected specimen revealed a fleshy, well-circumscribed, 7-cm mass., Histologically, there was a hypocellular to moderately hypercellular, bland spindle-cell proliferation admixed with a prominent infiltrate of lymphocytes, histiocytes, and plasma cells. The spindle cells were vimentin positive but negative for muscle markers; electron microscopy revealed only fibroblastic cells. DNA analysis revealed a diploid population with low S-phase fraction. The patient was well at 6-mo follow-up. It is important for the pathologist to be aware of the existence of this entity in unusual locations such as the pancreas so as to avoid a mistaken diagnosis of malignancy. |
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Keywords: | Pancreas pseudotumor inflammatory |
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