甲基强的松龙和地塞米松治疗放射性脑水肿的差异

目的研究甲基强的松龙及地塞米松治疗放射性脑水肿的差异。方法建立大鼠脑胶质瘤模型。实验分组：A组（大剂量甲基强的松龙组）、B组（小剂量甲基强的松龙组）、C组（地塞米松组）、D组（对照组）、E组（空白组）。各组均颅内种植肿瘤，于种植15天后A、B、C、D各组给予C060照射，A、B、C组大鼠照射前后分别给予甲基强的松龙和地塞米松治疗。测量大鼠脑水肿情况。结果治疗后，与其他各组比较，D组大鼠脑组织含水率最高，E组最低（P〈0．05）；C组大鼠脑组织含水率明显高于A、B两组（P〈0．05）；但A、B两组间无显著性差异（P〉O．05）。结论甲基强的松龙和地塞米松都可以有效防治放射性脑水肿，且甲基强的松龙比地塞米松疗效更好。

Comparsion between Curative effects of Methylprednisolone and Dexamethasone on Radiation Cerebral Edema

Objective To compare the curative effect of methylprednisolone on radiative cerebral edema with dexamethasone. Methods The intracranial glioma models were established in 100 rats who were divided into groups A (large dose methylprednisolone),B (small dose methylprednisolone),C (dexamethasone),D (control,being irradiated,but not given drugs),and E (blank,not irradiated and not given drugs). The brains were irradiated by Co60 15 days after the implantation of glioma cells in groups A,B,C and D. The content of cerebral water was determined. Results The content of cerebral water in group D was significantly higher than that in groups A,B,C and E (P<0.05). The content of cerebral water in group C was significantly higher than that in groups A and B (P<0.05). There were no significant difference in the content of cerebral water between group A and B (P>0.05). Conclusions Methylprednisolone and dexamethasone can effectively decrease radiation cerebral edema,and the curative effect of methylprednisolone on the radiation cerebral edema is better than that of dexamethasone.