Comparative evaluation of cell-free tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Comparative evaluation of cell-free tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer

Authors:	Heidi Schwarzenbach Klaus Pantel Birthe Kemper Cord Beeger Friedrich Otterbach Rainer Kimmig Sabine Kasimir-Bauer

Affiliation:	(1) Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany;(2) Department of Gynecology and Obstetrics, University of Duisburg-Essen, Sabinastrasse 20, 45136 Essen, Germany;(3) Institute of Pathology, University of Duisburg-Essen, Sabinastrasse 20, 45136 Essen, Germany

Abstract:	Introduction The origin and clinical relevance of circulating cell-free tumor DNA in the blood of cancer patients is still unclear. Here we investigated whether the detection of this DNA is related to bone marrow (BM) micrometastasis and tumor recurrence in breast cancer patients.

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