| 开管型3,5-二氯苯基氨基甲酸酯纤维素衍生物键合手性毛细管电色谱柱的制备及应用 |
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| 引用本文： | 杨清清,伍蓉,赵敬丹,狄斌,苏梦翔,吴夏冰,强淑萍,樊菲.开管型3,5-二氯苯基氨基甲酸酯纤维素衍生物键合手性毛细管电色谱柱的制备及应用[J].药物分析杂志,2011(11). |
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| 作者姓名： | 杨清清 伍蓉 赵敬丹 狄斌 苏梦翔 吴夏冰 强淑萍 樊菲 |
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| 作者单位： | 江苏省食品药品检验所;重庆市万州药品检验所;中国药科大学药物分析教研室;药物质量与安全预警教育部重点实验室; |
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| 摘 要： | 目的:制备键合型开管毛细管电色谱柱,用于手性药物分析。方法:合成了带有十一碳烯酰基的纤维素-三(3,5-二氯苯基氨基甲酸酯)衍生物,通过自由基聚合反应,将其键合于毛细管内壁,得到毛细管电色谱柱,并对手性药物进行色谱分离。结果:吡喹酮得到较好分离。结论:制备的毛细管柱对吡喹酮具有较好的识别能力,且柱效较高,对后续键合型开管毛细管电色谱柱的研究奠定了基础。
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| 关 键 词： | 纤维素 键合 对映体 自由基聚合 电色谱 手性拆分 手性固定相 吡喹酮 |
Preparation and application of open tubular capillary column containing covalently bound cellulose,tris(3,5-dichlorophenylcarbamate) as chiral selector |
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| YANG Qing-qing,WU Rong,ZHAO Jing-dan,DI Bin,SU Meng-xiang,WU Xia-bing,QIANG Shu-ping,FAN Fei.Preparation and application of open tubular capillary column containing covalently bound cellulose,tris(3,5-dichlorophenylcarbamate) as chiral selector[J].Chinese Journal of Pharmaceutical Analysis,2011(11). |
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| Authors: | YANG Qing-qing WU Rong ZHAO Jing-dan DI Bin SU Meng-xiang WU Xia-bing QIANG Shu-ping FAN Fei |
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| Institution: | YANG Qing-qing1,WU Rong2,ZHAO Jing-dan3,DI Bin3,4,SU Meng-xiang3,WU Xia-bing3,QIANG Shu-ping3,FAN Fei3 (1.Jiangsu Institute for Food and Drug Control,Nanjing 210008 China,2.Chongqing Wanzhou Institute for Drug Control,Chongqing 404000,China,3.Department of Pharmaceutical Analysis,China Pharmaceutical University,Nanjing 210009,4.Key Laboratory of Drug Quality Control and Pharmacovigilance,Ministry of Education,China) |
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| Abstract: | Objective:To prepare immobilized cellulose tris(3,5-dichlorophenylcarbamate)as chiral stationary phase on capillary column and study its properties on chiral drugs.Methods: Cellulose tris(3,5-dichlorophenylcarbamate)derivatives having a small amount of 10-undecenoyl groups were synthesized by a simple process and efficiently immobilized on capillary column by radical polymerization reaction with azobisisobutyronitrile(AIBN)as the initiator.The column was evaluated by chiral drugs.Results: D,L-praziquantel a... |
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| Keywords: | cellulose immobilization enantiomer radical polymerization capillary electro-chromatography(CEC) chiral separation chiarl stationary phase praziquantel |
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