| DART-质谱及其在药物分析中的应用 |
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| 引用本文： | 廖杰,刘娜,刘春胜. DART-质谱及其在药物分析中的应用[J]. 药物分析杂志, 2011, 0(10) |
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| 作者姓名： | 廖杰 刘娜 刘春胜 |
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| 作者单位： | 解放军总医院医学实验测试中心;华质泰科生物技术(北京)有限公司; |
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| 摘 要： | 介绍一种非表面接触型大气压解析/离子化质谱新技术—实时直接分析(DART)及其在药物定性、定量分析中的应用。在环境空气条件下,样品表面的化合物经中性或惰性气体(如氮气、氦气或氩气)放电产生的激发态原子瞬间脱附并离子化,以质谱或串联质谱检测。该技术无需样品预处理,或仅需要简单的样品前处理,具有抗基质干扰、无溶剂效应、分析周期短(2～3 s)、直接、原位、无损、快速和现场等特点。文中重点介绍了DART在药品鉴别、药物合成反应监测、药代动力学研究和滥用药物监测等方面的应用,并对该技术在药物分析领域中的应用前景进行了展望。
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| 关 键 词： | 实时直接分析(DART) 大气压离子化 质谱 药物分析 现场分析 打假 综述 |
Direct analysis in real time mass spectrometry and its applications to drug analysis |
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| LIAO Jie,LIU Na,LIU Chun-sheng. Direct analysis in real time mass spectrometry and its applications to drug analysis[J]. Chinese Journal of Pharmaceutical Analysis, 2011, 0(10) |
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| Authors: | LIAO Jie LIU Na LIU Chun-sheng |
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| Affiliation: | LIAO Jie1,LIU Na2,LIU Chun-sheng2(1.Medical and Experimental Analysis Center of PLA General Hospital,Beijing 100853,China,2.ASPEC Technologies Limited,Beijing 100102,China) |
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| Abstract: | Direct Analysis in Real Time(DART),a new ambient ionization technology,has been recently introduced to allow direct biological sample introduction into a mass spectrometry(MS) system.It enables analysis of molecules present in any phase,solid,liquid or in the vapor in seconds.The elimination of conventionally required sample preparation and separation by HPLC prior to MS or MS/MS analysis represents a remarkable opportunity to reduce assay turnaround time,environmental impact and capital/manpower investment... |
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| Keywords: | direct analysis in real time(DART) ambient ionization mass spectrometry pharmaceutical analysis in situ analysis crack down on counterfeit goods overview |
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